Apo B/Apo A-1联合TC/HDL-C在冠心病患者中的检测价值分析  

Detection value of Apo B/Apo A-1 combined with TC/HDL-C on patients with coronary heart disease

作　　者：王文秀 钟显姜 石冰冰 Wang Wen-xiu;Zhong Xian-jiang;Shi Bing-bing(Department of Laboratory Medicine,Duchang People’s Hospital,Jiujiang 332600,Jiangxi,China)

机构地区：[1]都昌县人民医院检验科,江西九江332600

出　　处：《四川生理科学杂志》2025年第4期781-783,858,共4页

摘　　要：目的:探讨载脂蛋白B(Apolipoprotein B,Apo-B)/载脂蛋白A1(Apolipoprotein A1,Apo-A1)联合总胆固醇(Total cholesterol,TC)/高密度脂蛋白胆固醇(High density lipoprotein cholesterol,HDL-C)在冠心病患者中的检测价值。方法:将我院2022年6月到2024年6月收治的62例冠心病患者纳入本次研究对象,按冠状动脉造影结果及冠状动脉复杂病变评分体系(Gensini)评分将患者分为轻度狭窄组32例(Gensini评分≤25分)和中重度狭窄组30例(Gensini评分>25分)。观察比较两组患者的Apo-B、Apo-A1、TC及HDL-C水平,使用受试者工作特征曲线分析Apo-B/Apo-A1联合TC/HDL-C对冠心病患者中重度冠状动脉狭窄的诊断价值。结果:中重度狭窄组患者BMI高于轻度狭窄组,糖尿病患病率比轻度狭窄组多(P<0.05);中重度狭窄组患者的Apo-B、TC水平及Apo-B/Apo-A1比值、TC/HDL-C比值均高于轻度狭窄组患者(P<0.05);Apo-A1、HDL-C水平均低于轻度狭窄组患者(P<0.05);受试者工作特征曲线显示,Apo-B/Apo-A1、TC/HDL-C及二者联合诊断中重度冠状动脉狭窄的曲线下面积分别为0.701、0.713、0.876,敏感度分别为70.00%、70.00%、66.67%,特异性分别为71.87%、68.75%、93.75%;二者联合对中重度冠状动脉狭窄的诊断效能最高(Z=2.161、2.182,P<0.05)。结论:冠心病患者冠状动脉狭窄程度与Apo-B/Apo-A1、TC/HDL-C1比值异常升高密切相关,监测患者Apo-B/Apo-A1、TC/HDL-C1比值有助于临床诊断冠心病病情进展情况。Objective:To investigate the detection value of apolipoprotein B(Apo-B)/apolipoprotein A1(Apo-A1)combined with total cholesterol(TC)/high density lipoprotein cholesterol(HDL-C)on patients with coronary heart disease.Methods:Totally 62 patients with coronary heart disease in the hospital from June 2022 to June 2024 were included in the study.According to the coronary angiography results and coronary artery complex lesion scoring system(Gensini)score,the patients were divided into 32 cases in mild stenosis group(Gensini score≤25 points)and 30 cases in moderate-to-severe stenosis group(Gensini score>25 points).The levels of Apo-B,Apo-A1,TC and HDL-C were observed and compared between groups.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of Apo-B/Apo-A1 combined with TC/HDL-C on moderate-to-severe coronary artery stenosis in patients with coronary heart disease.Results:The BMI of patients in moderate-to-severe stenosis group was higher than that in mild stenosis group,and the prevalence of diabetes mellitus was higher than that in mild stenosis group(P<0.05).The Apo-B,TC,Apo-B/Apo-A1 ratio and TC/HDL-C ratio in moderate-to-severe stenosis group were higher(P<0.05)while the levels of Apo-A1 and HDL-C were lower than those in mild stenosis group(P<0.05).ROC curve showed that the areas under the curves(AUCs)of Apo-B/Apo-A1,TC/HDL-C and their combination in the diagnosis of moderate-to-severe coronary artery stenosis in patients with coronary heart disease were 0.701,0.713 and 0.876,and the sensitivities were 70.00%,70.00%and 66.67%,and the specificities were 71.87%,68.75%and 93.75%respectively.The combination of the two had the highest diagnostic efficiency on moderate-to-severe coronary artery stenosis(Z=2.161,2.182,P<0.05).Conclusion:The degree of coronary artery stenosis in patients with coronary heart disease is closely related to the abnormal increases of Apo-B/Apo-A1 ratio and TC/HDL-C1 ratio.Monitoring the Apo-B/Apo-A1 ratio and TC/HDL-C1 ratio is helpful for clinical diagn

关 键 词：载脂蛋白B 载脂蛋白A1 总胆固醇 高密度脂蛋白胆固醇 冠心病 冠状动脉狭窄 

分 类 号：R541.4[医药卫生—心血管疾病]