石斛玉女煎联合羟氯喹对干燥综合征患者的治疗效果研究  

Effect of Dendrobium Yunv decoction combined with hydroxychloroquine on patients with Sjögren's syndrome

作　　者：陈岩 李婉 Chen Yan;Li Wan(Department of Geriatrics,Nanyang Hospital of Traditional Chinese Medicine,Nanyang 473007,Henan,China)

机构地区：[1]南阳市中医院老年病科,河南南阳473007

出　　处：《四川生理科学杂志》2025年第4期806-808,914,共4页

摘　　要：目的:分析石斛玉女煎联合羟氯喹治疗干燥综合征的临床疗效。方法:选取2022年8月~2024年1月期间本院收治的86例干燥综合征患者作为研究对象,采用随机数字表法分为对照组和研究组,各43例。对照组患者口服硫酸羟氯喹片治疗,研究组患者在对照组的基础上联合石斛玉女煎治疗,两组均服用3m。分析比较两组的临床疗效,治疗前后的临床症状评分[干燥综合征疾病活动指数(EULAR Sjögren's Syndrome Disease Activity Index,ESSDAI)、干燥综合征自我感受表(EULAR Sjögren's syndrome patient reported index,ESSPRI)]、实验室指标[唾液流率(Saliva flow rate,SFR)、泪液分泌试验(Schirmer test,ST)、泪膜破碎时间],采用免疫比浊法、速率散射比浊法检测两组治疗前后血清因子[红细胞沉降率(Erythrocyte sedimentation rate,ESR)、类风湿因子(Rheumatoid factor,RF)、C反应蛋白(C-reactive protein,CRP)、免疫球蛋白G(Immunoglobulin g,IgG)]水平及治疗期间不良反应。结果:研究组的临床总有效率明显高于对照组(P<0.05)。治疗后,两组的ESSDAI、ESSPRI评分、CRP、RF、IgG、ESR水平均比治疗前明显降低,且研究组均明显低于对照组(P<0.05);两组的SFR、泪膜破碎时间、ST水平均比治疗前明显提高,且研究组均比对照组明显提高(P<0.05)。两组的不良反应发生率无明显差异(P>0.05)。结论:石斛玉女煎联合羟氯喹治疗干燥综合征患者,能提高治疗效果,改善患者临床症状,调节免疫功能,促进病情恢复。Objective:To analyze the clinical efficacy of Dendrobium Yunv decoction combined with hydroxychloroquine in the treatment of Sjögren's syndrome.Methods:Eighty-six patients with Sjögren's syndrome diagnosed and treated to our hospital from August 2022 to January 2024 were selected as the study objects,the patients were divided into control group and study group by random number table,with 43 cases in each group.The patients in control group were treated with oral hydroxychloroquine tablets,the patients in study group were treated Dendrobium Yunv decoction on the basis of the control group,and both groups were administered for 3 months.The clinical efficacy,and adverse reactions during treatment were analyzed and compared between the two groups,as well as the clinical symptom scores[EULAR Sjögren's Syndrome Disease Activity Index(ESSDAI),EULAR Sjögren's syndrome patient reported index(ESSPRI)],laboratory indicators[Saliva flow rate(SFR),Schirmer test(ST),tear film breakup time]before and after treatment.The levels of serum factors[Erythrocyte sedimentation rate(ESR),Rheumatoid factor(RF),C-reactive protein(CRP),Immunoglobulin g(IgG)]were detected using immunoturbidimetry and rate nephelometry before and after treatment in both groups.Results:The total clinical effective rate of the study group was significantly higher than that of the control group(P<0.05).After treatment,the ESSDAI,ESSPRI scores,CRP,RF,IgG,and ESR levels in both groups were significantly lower than those before treatment,and the study group was significantly lower than the control group(P<0.05).The SFR,tear film breakup time,and ST levels in both groups were significantly improved compared with those before treatment,and the study group showed a significant improvement compared with the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Dendrobium Yunv decoction combined with hydroxychloroquine can improve the therapeutic effect,improve the clinical symptoms

关 键 词：干燥综合征 石斛 玉女煎 羟氯喹 疗效 

分 类 号：R259[医药卫生—中西医结合]