马来酸麦角新碱联合卡前列素氨丁三醇对剖宫产产妇凝血功能影响及安全性分析  

Analysis of the effect of ergonovine maleate combined with carboprost tromethamine on the coagulation function of cesarean section mothers and the safety of the combination of ergonovine maleate and carboprost tromethamine

作　　者：程存 袁婷婷 张婧喆 Cheng Cun;Yuan Ting-ting;Zhang Jing-zhe(Department of Obstetrics and Gynecology,Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院妇产科,河南南阳473000

出　　处：《四川生理科学杂志》2025年第4期820-822,829,共4页

摘　　要：目的:探讨剖宫产产妇采用马来酸麦角新碱与卡前列素氨丁三醇(欣母沛)联合方案的安全性及对产妇凝血功能的影响。方法:选取2021年5月至2024年5月我院收治的90例剖宫产产妇作为研究对象,按照随机数字表法分为麦角组、欣母沛组和联合组,各30例。麦角组剖宫产后应用缩宫素注射液联合马来酸麦角新碱注射液,欣母沛组剖宫产后应用缩宫素注射液联合卡前列素氨丁三醇注射液,联合组剖宫产后应用缩宫素注射液联合马来酸麦角新碱注射液和卡前列素氨丁三醇注射液。评估对比三组产后出血情况、凝血功能、子宫复旧情况及安全性。结果:麦角组与欣母沛组产后2 h、24 h出血量、产后3 d、5 d子宫下降高度和恶露持续时间均无明显差异(P>0.05);联合组产后2 h、24 h出血量和产后出血发生率均明显低于麦角组、欣母沛组,产后3 d、5 d子宫下降高度明显大于麦角组、欣母沛组,恶露持续时间明显短于麦角组、欣母沛组(P<0.05)。产前,三组活化凝血酶原时间(Activated Partial Thromboplastin Time,APTT)、纤维蛋白原水平(Fibrinogen,FIB)、凝血酶原时间(Prothrombin Time,PT)和D二聚体(D-dimer,D-D)水平均无明显差异(P>0.05);产后,麦角组与欣母沛组各项凝血功能指标水平无明显差异(P>0.05),联合组各项凝血功能指标水平均明显低于麦角组、欣母沛组(P<0.05)。三组不良反应发生率无明显差异(P<0.05)。结论:剖宫产产妇应用马来酸麦角新碱联合卡前列素氨丁三醇具有较高的安全性,其在减少产妇术后出血量,改善凝血功能及促进子宫复旧方面效用显著。Objective:To investigate the safety and effect on maternal coagulation of a combined regimen of ergonovine maleate and carboprost tromethamine(Hemabate)in women undergoing caesarean section.Methods:A total of 90 cesarean delivery patients admitted to our hospital fromMay 2021 toMay 2024 were selected as research subjects and randomly divided into three groups:the Ergometrine group,the Oxytocin group,and the Combined group,with 30 cases in each group.The Ergometrine group received Oxytocin injection combined with Ergometrine maleate injection after cesarean delivery,the Oxytocin group received Oxytocin injection combined with Carboprost tromethamine injection after cesarean delivery,and the Combined group received Oxytocin injection combined with both Ergometrine maleate injection and Carboprost tromethamine injection after cesarean delivery.The study assessed and compared postpartum hemorrhage,coagulation function,uterine recovery,and safety among the three groups.Results:There were no significant differences in the amount of bleeding at 2 hours and 24 hours postpartum,the height of uterine descent at 3 days and 5 days postpartum,and the duration of lochia between the Ergometrine group and the Oxytocin group(P>0.05).The Combined group had significantly lower amounts of bleeding at 2 hours and 24 hours postpartum and a lower incidence of postpartum hemorrhage compared to the Ergometrine and Oxytocin groups.Additionally,the height of uterine descent at 3 days and 5 days postpartum was significantly greater in the Combined group than in the Ergometrine and Oxytocin groups,and the duration of lochia was significantly shorter in the Combined group(P<0.05).Preoperatively,there were no significant differences in activated partial thromboplastin time(APTT),fibrinogen levels(FIB),prothrombin time(PT),and D-dimer(D-D)levels among the three groups(P>0.05).Postoperatively,there were no significant differences in coagulation function indicators between the Ergometrine group and the Oxytocin group(P>0.05),while all coagulation

关 键 词：马来酸麦角新碱 纤维蛋白原 卡前列素氨丁三醇 剖宫产 

分 类 号：R719.8[医药卫生—妇产科学]