地塞米松磷酸钠注射液联合注射用美罗培南治疗儿童化脓性脑膜炎血清氧化应激指标的影响  

Effects of dexamethasone sodium phosphate injection combined with meropenem for injection on serum oxidative stress indexes in children with purulent meningitis

作　　者：张萌 张森 王梦 梁莉红 Zhang Meng;Zhang Sen;Wang Meng;Liang Li-hong(Department of Pediatrics,Kaifeng Children's Hospital,Kaifeng 475000,China;Department of Pediatrics,Henan Children's Hospital(Zhengzhou Children's Hospital)Zhengzhou 450000,China)

机构地区：[1]开封市儿童医院儿内科,河南开封475000 [2]河南省儿童医院郑州儿童医院儿内科,河南郑州450000

出　　处：《四川生理科学杂志》2025年第4期897-899,共3页

摘　　要：目的:探究地塞米松磷酸钠注射液联合注射用美罗培南治疗儿童化脓性脑膜炎(Purulentmeningitis,PM)血清氧化应激指标的影响。方法:参照随机数字表法将2022年10月至2024年10月医院收治的90例PM患儿分为对照组(n=45例,静脉滴注美罗培南30 mg·kg^(-1))与联合组(n=45例,在对照组基础上静脉滴注地塞米松磷酸钠注射液10 mg)治疗7 d。评估临床疗效,并于治疗前后分别采用黄嘌呤氧化酶法、硫代巴比妥酸法、硝酸还原酶法分别检测氧化应激指标,如超氧化物歧化酶(Superoxide dismutase,SOD)、丙二醛(Malondialdehyde,MDA)、一氧化氮(Nitric oxide,NO)水平,以及采用酶联免疫吸附法检测C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor necrosis factor-α,TNF-α)、降钙素原(Procalcitonin,PCT)水平;同时记录治疗期间不良反应。结果:联合组治疗效果优于对照组(P<0.05)。与治疗前相比,两组SOD均升高,MDA、NO、CRP、TNF-α、PCT均下降(P<0.05),其中联合组更为显著(P<0.05)。两组不良反应发生率比较无明显差异(P>0.05)。结论:地塞米松磷酸钠注射液联合注射用美罗培南治疗儿童PM有较好疗效,可减轻氧化应激和炎症反应,且安全性良好。Objective:To explore the effects of dexamethasone sodium phosphate injection combined with meropenem for injection on serum oxidative stress indexes in children with purulentmeningitis(PM).Methods:According to random number table method,90 children with PM admitted to the hospital were divided into control group(n=45,intravenous drip of 30 mg·kg^(-1)meropenem)and combination group(n=45,intravenous drip of 10 mg dexamethasone sodium phosphate injection on basis of control group)between October 2022 and October 2024.After 7 days of treatment,clinical curative effect was evaluated.Before and after treatment,oxidative stress indexes,such as superoxide dismutase(SOD),malondialdehyde(MDA),nitric oxide(NO)were detected by xanthine oxidase method,thiobarbituric acid method and nitrate reductase method,respectively.The levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and procalcitonin(PCT)were detected by enzyme-linked immunosorbent assay,and adverse reactions during treatment were recorded.Results:The curative effect of combination group was better than that of control group(P<0.05).After treatment,SOD was increased,while MDA,NO,CRP,TNF-αand PCT were deceased in both groups(P<0.05),and changes of the above indexes were more significant in combination group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The curative effect of dexamethasone sodium phosphate injection combined with meropenem for injection is good in PM children,which can relieve oxidative stress and inflammatory response,with good safety.

关 键 词：地塞米松磷酸钠注射液 注射用美罗培南 儿童 化脓性脑膜炎 氧化应激 

分 类 号：R725.1[医药卫生—儿科]