胰岛素泵皮下连续输注治疗糖尿病酮症酸中毒的临床效果观察  

Clinical effect of continuous subcutaneous infusion of insulin pump on diabetes ketoacidosis

作　　者：韩乐 Han Le(Emergency Department,Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院急诊科,河南南阳473000

出　　处：《四川生理科学杂志》2025年第4期930-933,共4页

摘　　要：目的:探究胰岛素泵皮下连续输注治疗糖尿病酮症酸患者(Diabetic Ketoacidosis,DKA)的临床效果。方法:选取2024年3月至2025年1月我院收治的90例DKA患者作为研究对象,按随机数字表法分为观察组和对照组,各45例。对照组采用小剂量胰岛素治疗,观察组采用胰岛素皮下连续输注治疗。比较两组治疗效果、血糖、血气指标、酮体水平、胰岛素用量、酸中毒指标、炎症因子及不良反应。结果:治疗后,观察组PH值恢复正常时间、血酮体转阴时间、尿酮体转阴时间均明显短于对照组,观察组胰岛素用量、血糖、血乳酸(Lactic Acid,Lac)、β-羟丁酸(β-Hydroxybutyric acid,β-HB)及炎症因子水平均明显低于对照组(P<0.05);观察组治疗总有效率、硫胺素、二氧化碳结合力中(Carbon Dioxide Combining Power,CO2CP)水平均明显高于对照组(P<0.05)。两组药物安全性无明显差异(P>0.05)。结论:DKA患者采用胰岛素泵皮下连续输注治疗效果较好,可降低患者血糖水平,抑制炎症反应,减少胰岛素使用量,缩短PH值恢复正常时间及血酮体、尿酮体转阴时间,纠正酸中毒,促进患者转归,且药物安全性理想。Objective:To explore the clinical effect of continuous subcutaneous infusion of insulin pump in the treatment of(Diabetic Ketoacidosis,DKA).Methods:Ninety patients with DKA admitted to our hospital from March 2024 to January 2025 were selected as the research subjects and randomly divided into an observation group and a control group,with 45 cases in each group,using a random number table method.The control group was treated with low-dose insulin,while the observation group was treated with continuous subcutaneous insulin infusion.Compare the therapeutic effects,blood glucose,blood gas indicators,ketone body levels,insulin dosage,acidosis indicators,inflammatory factors,and adverse reactions between two groups.Results:After treatment,the observation group had significantly shorter recovery time of pH value,negative conversion time of blood ketones,and negative conversion time of urine ketones compared to the control group;the observation group had significantly lower insulin dosage,blood glucose,lactate(Lactic Acid,Lac),(β-hydroxybutyric acid,β-HB),and inflammatory factor levels compared to the control group(P<0.05);the total effective rate,levels of thiamine and carbon dioxide binding power(CO2CP)in the observation group were significantly higher than those in the control group(P<0.05).There was no significant difference in safety between the two groups of drugs(P>0.05).Conclusion:Subcutaneous continuous infusion of insulin pump has a good therapeutic effect on DKA patients,which can lower their blood glucose levels,inhibit inflammatory reactions,reduce insulin use,shorten the time for pH to return to normal and the time for blood and urine ketone bodies to turn negative,correct acidosis,promote patient recovery,and have ideal drug safety.

关 键 词：糖尿病酮症酸中毒 胰岛素 皮下连续输注式 血糖 炎症因子 

分 类 号：R587.2[医药卫生—内分泌] R587.1[医药卫生—内科学]