纤支镜肺泡灌洗术配合盐酸氨溴索治疗肺部感染患者的临床效果观察  

Clinical Observation of Bronchoscopic Alveolar Lavage Combined with Ambroxol Hydrochloride in the Treatment of Patients with Pulmonary Infection

作　　者：莫秀丽 叶品钊 李惠燕 Mo Xiuli(Fengkai Hospital of Traditional Chinese Medicine,Fengkai 526500)

机构地区：[1]封开县中医院,广东封开526500

出　　处：《黑龙江医药》2025年第2期263-266,共4页Heilongjiang Medicine journal

基　　金：肇庆市科技创新指导类项目(项目编号:2023040309023)。

摘　　要：目的:探讨肺部感染患者采用纤支镜肺泡灌洗术配合盐酸氨溴索治疗的临床疗效。方法:于2023年1月至2024年10月纳入100例肺部感染患者,采用随机数字表法将患者分为对照组(应用盐酸氨溴索治疗,n=50)与联合组(应用纤支镜肺泡灌洗术配合盐酸氨溴索治疗,n=50)。连续治疗7天后评估治疗效率,记录症状消失时间,比较治疗前后动脉血气指标水平[动脉血二氧化碳分压(PaCO_(2))与动脉血氧分压(PaO_(2))]、血常规[中性粒细胞(NEU)和白细胞计数(WBC)]、炎性指标水平[降钙素原(PCT)、C反应蛋白(CRP)],观察不良反应发生情况。结果:联合组治疗有效率为98.00%,高于对照组的80.00%(P<0.05)。联合组咳痰、干咳、呼吸困难、高热症状消失时间,均比对照组短(P<0.05)。治疗后,两组PaCO_(2)、NEU、WBC、PCT、CRP水平降低,PaO_(2)水平上升,并且联合组PaCO_(2)、NEU、WBC、PCT、CRP水平比对照组低,PaO_(2)水平比对照组高(P<0.05)。两组不良反应发生率相比无明显差异(P>0.05)。结论:肺部感染患者联合应用纤支镜肺泡灌洗术与盐酸氨溴索治疗的临床效果理想,能促进动脉血气和外周血象改善,降低炎性指标水平。Objective:To investigate the clinical effect of bronchoscopic alveolar lavage combined with ambroxol hydrochloride in the treatment of patients with pulmonary infection.Methods:100 patients with pulmonary infection were enrolled from January 2023 to October 2024,and were divided into control group(treated with ambroxol hydrochloride,n=50)and combination group(treated with bronchoscopic alveolar lavage combined with ambroxol hydrochloride,n=50)by random number table method.After 7 days of continuous treatment,the efficacy of treatment was evaluated and the time of symptom resolution was recorded.The levels of arterial blood gas indexes[PaCO_(2)and PaO_(2)],routine blood routine[neutrophil(NEU)and white blood cell(WBC)]and inflammatory indexes[procalcitonin(PCT)and C-reactive protein(CRP)]before and after treatment were compared to observe the occurrence of adverse reactions.Results:The effective rate of combination group was 98.00%,higher than that of control group 80.00%(P<0.05).The symptoms of expectoration,dry cough,dyspnea and hyperpyrexia in the combined group were shorter than those in the control group(P<0.05).After treatment,the levels of PaO_(2),NEU,WBC,PCT and CRP in the two groups were decreased,while the level of PaO_(2)was increased,and the levels of PaCO_(2),NEU,WBC,PCT and CRP in the combination group were lower than those in the control group,while the level of PaO_(2)was higher than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The combination of bronchoscopic alveolar perfusion and ambroxol hydrochloride in patients with pulmonary infection has ideal clinical effect,which can promote the improvement of arterial blood gas and peripheral blood image,and reduce the level of inflammatory indicators.

关 键 词：肺部感染 纤支镜肺泡灌洗术 盐酸氨溴索 炎性指标水平 

分 类 号：R563[医药卫生—呼吸系统]