经鼻高流量湿化氧疗对慢性阻塞性肺疾病合并2型呼吸衰竭患者血气分析指标的影响  

Effect of High-Flow Nasal Cannula Oxygen Therapy on Blood Gas Analysis Parameters in Patients with Chronic Obstructive Pulmonary Disease Complicated by Type 2 Respiratory Failure

作　　者：周官发 万江春 邹荣华 李建卫 Zhou Guanfa(Dongxiang District People’s Hospital of Fuzhou City,Fuzhou Jiangxi 331800)

机构地区：[1]抚州市东乡区人民医院,江西抚州33180

出　　处：《黑龙江医药》2025年第2期458-462,共5页Heilongjiang Medicine journal

摘　　要：目的:探究经鼻高流量湿化氧疗对慢性阻塞性肺疾病(COPD)合并2型呼吸衰竭患者的应用效果。方法:按照随机数字表法将抚州市东乡区人民医院收治的68例COPD合并2型呼吸衰竭患者分为两组,病例选取时间为2021年8月至2024年8月,每组各纳入患者34例。对照组采用常规鼻导管低流量辅助治疗,研究组采用经鼻高流量湿化吸氧辅助治疗,两组均连续治疗3天。比较两组血气分析指标、体征相关指标及不良反应。结果:两组治疗前血气分析指标、体征相关指标比较,无统计学差异(P>0.05);两组治疗后血气分析指标及体征相关指标均改善,且研究组二氧化碳分压(PaCO_(2))、心率(HR)、呼吸频率(RR)均低于对照组,动脉血氧分压(PaO_(2))、pH值高于对照组,有统计学差异(P<0.05);与对照组相比,研究组不良反应发生率较低,有统计学差异(P<0.05)。结论:COPD合并2型呼吸衰竭患者采用经鼻高流量湿化吸氧辅助治疗,利于改善患者生命体征,调节血气分析指标,且不良反应较少,值得临床推广使用。Objective:To explore the efficacy of high-flow nasal cannula(HFNC)oxygen therapy in patients with chronic obstructive pulmonary disease(COPD)complicated by type 2 respiratory failure.Methods:A total of 68 COPD patients with type 2 respiratory failure admitted to Dongxiang District People’s Hospital of Fuzhou City from August 2021 to August 2024 were divided into two groups using a random number table,with 34 patients in each group.The control group received conventional low-flow nasal cannula oxygen therapy,while the study group received HFNC oxygen therapy.Both groups were treated continuously for 3 days.Blood gas analysis parameters,vital signs,and adverse reactions were compared between the two groups.Results:Before treatment,there were no significant differences in blood gas analysis parameters or vital signs between the two groups(P>0.05).After treatment,both groups showed improvements in blood gas analysis parameters and vital signs.However,the study group exhibited significantly lower partial pressure of carbon dioxide(PaCO_(2)),heart rate(HR),and respiratory rate(RR)compared to the control group,while the partial pressure of oxygen(PaO_(2))and pH were higher(P<0.05).Additionally,the incidence of adverse reactions was lower in the study group(P<0.05).Conclusion:HFNC oxygen therapy for COPD patients with type 2 respiratory failure can effectively improve vital signs,regulate blood gas analysis parameters,and reduce adverse reactions,making it worthy of clinical promotion.

关 键 词：慢性阻塞性肺疾病合并2型呼吸衰竭 经鼻高流量湿化氧疗 血气分析指标 生命体征 

分 类 号：R563[医药卫生—呼吸系统]