血脂蛋白相关磷脂酶A2、同型半胱氨酸和超敏C反应蛋白在诊断缺血性脑卒中的价值分析  

Analysis of the Value of Detection of Lipoprotein-associated Phospholipase A2,Homocysteine and High-sensitivity C-reactive Protein in the Diagnosis of Ischemic Stroke

作　　者：王海革 刘玉锋 张磊 孙斌 WANG Haige;LIU Yufeng;ZHANG Lei;SUN Bin(Department of Blood Transfusion,Jiaozhou Central Hospital of Qingdao,Qingdao 266300,Shandong,China;Department of Laboratory,Jiaozhou Central Hospital of Qingdao,Qingdao 266300,Shandong,China)

机构地区：[1]青岛市胶州中心医院输血科,山东青岛266300 [2]青岛市胶州中心医院检验科,山东青岛266300

出　　处：《系统医学》2025年第5期52-54,58,共4页Systems Medicine

摘　　要：目的分析同型半胱氨酸(homocysteine,Hcy)、血脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)联合超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)诊断缺血性脑卒中的价值。方法非随机选取2020年1月—2023年11月青岛市胶州中心医院收治的60例缺血性脑卒中患者(经磁共振成像检查确诊)为研究组;非随机选取同期50名健康体检者为对照组。比较两组Hcy、Lp-PLA2、hs-CRP水平,分析Hcy、Lp-PLA2、hs-CRP单独及联合检测的诊断效能。结果研究组hs-CRP、Hcy、Lp-PLA2水平高于对照组,差异有统计学意义(P均<0.05)。hs-CRP+Hcy+Lp-PLA2联合诊断的特异度、灵敏度、准确度分别为98.00%(49/50)、96.67%(58/60)、97.27%(107/110),hs-CRP特异度、灵敏度、准确度分别为80.00%(40/50)、66.67%(40/60)、72.73%(80/110),Hcy特异度、灵敏度、准确度分别为70.00%(35/50)、55.00%(33/60)、61.82%(68/110),Lp-PLA2特异度、灵敏度、准确度分别为68.00%(34/50)、51.67%(31/60)、59.09%(65/110),联合诊断的诊断效能高于单一指标诊断,差异有统计学意义(P均<0.05)。结论hs-CRP+Hcy+Lp-PLA2联合检测缺血性脑卒中具有较高的灵敏度、特异度、准确度。Objective To analyse the value of homocysteine(Hcy),lipoprotein associated phospholipase A2(Lp-PLA2)combination with high-sensitivity C-reactive protein(hs-CRP)for the diagnosis of ischaemic stroke.Methods Sixty ischemic stroke patients(diagnosed by magnetic resonance imaging)admitted to Jiaozhou Central Hospital of Qingdao from January 2020 to November 2023 were non-randomly selected as the study group;fifty healthy medical check-ups during the same period were non-randomly selected as the control group.The levels of Hcy,Lp-PLA2,and hs-CRP were compared between the two groups,and the diagnostic efficacy of Hcy,Lp-PLA2,and hs-CRP alone and in combination was analysed.Results The levels of hs-CRP,Hcy,and Lp-PLA2 in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The specificity,sensitivity,and accuracy of the combined diagnosis of hs-CRP+Hcy+Lp-PLA2 were 98.00%(49/50),96.67%(58/60),and 97.27%(107/110),respectively.The specificity,sensitivity,and accuracy of hs-CRP were 80.00%(40/50),66.67%(40/60),and 72.73%(80/110),respectively.The specificity,sensitivity,and accuracy of Hcy were 70.00%(35/50),55.00%(33/60),and 61.82%(68/110),respectively.The specificity,sensitivity,and accuracy of Lp-PLA2 were 68.00%(34/50),51.67%(31/60),and 59.09%(65/110),respectively.The diagnostic efficacy of the combined diagnosis was higher than those of the single-indicator diagnosis,and the differences were statistically significant(all P<0.05).Conclusion The combined detection of ischaemic stroke by hs-CRP+Hcy+Lp-PLA2 has high sensitivity,specificity and accuracy.

关 键 词：缺血性脑卒中 血脂蛋白相关磷脂酶A2 同型半胱氨酸 超敏C反应蛋白 灵敏度 准确度 

分 类 号：R4[医药卫生—临床医学]