甲胎蛋白联合血小板检测诊断乙型肝炎肝硬化肝癌的价值分析  

Value Analysis of Combined Detection of Alpha Fetoprotein and Platelets in the Diagnosis of Hepatitis B,Cirrhosis,and Liver Cancer

作　　者：杨姣婧 徐冉冉 陈晓波 YANG Jiaojing;XU Ranran;CHEN Xiaobo(Clinical Laboratory,Rudong County Hospital of Traditional Chinese Medicine,Nantong 226400,Jiangsu,China)

机构地区：[1]如东县中医院检验科,江苏南通226400

出　　处：《系统医学》2025年第5期78-80,88,共4页Systems Medicine

摘　　要：目的分析甲胎蛋白、血小板联合诊断乙型肝炎肝硬化肝癌的价值。方法目的选取2023年3月—2024年3月如东县中医院收治的76例乙型肝炎肝硬化肝癌患者作为观察组,同期76名体检健康者为对照组,均检测甲胎蛋白及血小板指标(血小板比积、血小板分布宽度、血小板计数、血小板平均体积),比较甲胎蛋白、血小板指标单独及联合检测的诊断效能。结果观察组乙型肝炎肝硬化肝癌患者甲胎蛋白值高于对照组,血小板四项值低于对照组,差异有统计学意义(P均<0.05)。甲胎蛋白及血小板指标联合检测的灵敏度为98.68%(75/76)、准确度为98.68%(150/152),高于甲胎蛋白的88.16%(67/76)、93.42%(142/152),以及血小板的90.79%(69/76)%、95.39%(145/152),三种方式比较,差异有统计学意义(χ^(2)=6.611、5.382,P均<0.05)。结论临床诊断乙型肝炎肝硬化肝癌疾病可联合甲胎蛋白、血小板检测,此方式具有高灵敏度及高准确度。Objective To analyze the value of alpha-fetoprotein and platelet in the diagnosis of hepatocellular carcinoma with hepatitis B cirrhosis.Methods Seventy-six patients with hepatitis B cirrhosis and liver cancer admitted to Rudong County Hospital of Traditional Chinese Medicine from March 2023 to March 2024 were purposefully selected as the observation group,and seventy-six healthy subjects were selected as the control group during the same period.Alpha-fetoprotein and platelet indexes(platelet ratio,platelet distribution width,platelet count and mean platelet volume)were detected.To compare the diagnostic efficiency of alpha-fetoprotein and platelet indexes by single and combined detection.Results The values of alpha-fetoprotein and platelet in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The sensitivity and accuracy of the combined detection of A-fetoprotein and platelet indexes were 98.68%(75/76)and 98.68%(150/152),higher than 88.16%(67/76)and 93.42%(142/152)of A-fetoprotein,and 90.79%(69/76)and 95.39%(145/152)of platelet,three methods were compared,the differences were statistically significant(χ^(2)=6.611,5.382,both P<0.05).Conclusion The clinical diagnosis of hepatitis B cirrhosis and liver cancer can be combined with alpha-fetoprotein and platelet detection,which has high sensitivity and high accuracy.

关 键 词：甲胎蛋白 血小板 诊断 乙型肝炎肝硬化肝癌 

分 类 号：R446[医药卫生—诊断学]