瑞马唑仑对全麻下行全髋关节置换术老年患者苏醒效果及认知功能的影响  

The Effect of Remazolam on the Awakening Effect and Cognitive Function of Elderly Patients Undergoing Total Hip Arthroplasty Under General Anesthesia

作　　者：程慧慧 葛莹 王晗 CHENG Huihui;GE Ying;WANG Han(Department of Anesthesiology,Sihong Hospital,Sihong 223900,Jiangsu,China)

机构地区：[1]泗洪医院麻醉科,江苏泗洪223900

出　　处：《系统医学》2025年第5期89-92,共4页Systems Medicine

摘　　要：目的分析瑞马唑仑对全麻下行全髋关节置换术老年患者苏醒效果及认知功能的影响。方法非随机选取泗洪医院于2022年8月—2023年12月收治的118例全髋关节置换术的老年患者为研究对象。根据麻醉方式不同分为对照组、观察组,各59例。对照组实施静脉注射丙泊酚+舒芬太尼+维库溴铵诱导麻醉,观察组实施静脉注射瑞马唑仑+舒芬太尼+维库溴铵进行诱导。比较两组各时间点的血流动力学指标、苏醒情况及认知功能。结果观察组脑电双频指数值<60时刻、插管时刻的心率、平均动脉压波动情况均优于对照组,差异有统计学意义(P均<0.05)。观察组术后睁眼时间为(7.21±1.01)min、拔管时间为(12.62±4.68)min、麻醉后恢复室停留时间为(25.06±3.95)min、Riker镇静-躁动量表评分为(3.47±0.61)分,均优于对照组的(8.56±1.47)min、(15.43±5.10)min、(29.25±4.34)min、(4.02±1.24)分,差异有统计学意义(t=5.814、3.118、5.484、3.057,P均<0.05)。观察组术后认知功能评分优于对照组,差异有统计学意义(P均<0.05)。结论对于全麻下行全髋关节置换术老年患者,在麻醉诱导中联合瑞马唑仑更具优势,其对认知功能的影响较小,且苏醒恢复期较为稳定。Objective To analyze the effect of remazolam on the recovery effect and cognitive function of elderly patients undergoing total hip arthroplasty under general anesthesia.Methods A total of 118 elderly patients with total hip arthroplasty admitted to Sihong Hospital from August 2022 to December 2023 were non-randomly selected as the study subjects.According to different anesthesia methods,they were divided into control group and observation group,with 59 cases in each group.The control group was given intravenous injection of propofol+sufentanil+vecuronium bromide to induce anesthesia,the observation group was induced by intravenous injection of remazolam+sufentanil+vecuronium bromide.The hemodynamic indexes,recovery effect and cognitive function at each time point were compared between the two groups.Results The fluctuation of heart rate and mean arterial pressure at the time of bispectral index<60 and intubation in the observation group were better than those in the control group,and the differences were statistically significant(all P<0.05).The postoperative eye opening time,extubation time,PACA residence time and SAS score of the observation group were(7.21±1.01)min,(12.62±4.68)min,(25.06±3.95)min and 3.47±0.61,which were better than(8.56±1.47)min,(15.43±5.10)min,(29.25±4.34)min and 4.02±1.24 of the control group,the differences were statistically significant(t=5.814,3.118,5.484,3.057,all P<0.05).The postoperative cognitive function score of the observation group were better than that of the control group,and the differences were statistically significant(all P<0.05).Conclusion For elderly patients undergoing total hip arthroplasty under general anesthesia,combined with remazolam has more advantages in anesthesia induction,and it has less impact on cognitive function.

关 键 词：全髋关节置换术 全身麻醉 瑞马唑仑 血流动力学指标 苏醒效果 认知功能 

分 类 号：R614[医药卫生—麻醉学]