PPI三联治疗对Hp感染患儿的Hp根除率及复发率的影响分析  

Analysis of the Effect of PPI Triple Therapy on Hp Eradication Rate and Recurrence Rate in Children with Hp Infection

作　　者：王同涛 王蕊 WANG Tongtao;WANG Rui(General Pediatrics,Caoxian People's Hospital,Heze 274000,Shandong,China)

机构地区：[1]曹县人民医院普儿科,山东菏泽274400

出　　处：《系统医学》2025年第5期161-163,167,共4页Systems Medicine

摘　　要：目的探讨质子泵抑制剂(proton pump inhibitors,PPI)三联治疗对幽门螺杆菌(helicobacter pylori,Hp)感染患儿的Hp根除率及复发率的影响。方法非随机选取2021年1月—2023年11月曹县人民医院收治的100例Hp感染患儿为研究对象。根据治疗方案差异分组,各50例。对照组行常规治疗,研究组联用PPI三联疗法。对比两组疗效、不良反应发生率。结果研究组总有效率为96.00%(48/50),高于对照组的84.00%(42/50),差异有统计学意义(χ^(2)=4.000,P<0.05)。相较于对照组,研究组Hp根除率更高,复发率、不良反应发生率更低,差异有统计学意义(P均<0.05)。结论Hp感染患儿采用PPI三联治疗,临床疗效理想,可有效提升Hp根除率,减少复发与用药不良反应发生率。Objective To investigate the effects of triple therapy with proton pump inhibitors(PPI)on the eradication rate and recurrence rate of helicobacter pylori(Hp)in children infected with Hp.Methods 100 children with Hp infection admitted to Caoxian People's Hospital from January 2021 to November 2023 were non-randomly selected as the study objects.There were 50 cases in each group according to different treatment plans.The efficacy,incidence of adverse reactions were compared between the two groups.Results The total effective rate of the study group was 96.00%(48/50),which was higher than 84.00%(42/50)of the control group,the difference was statistically significant(χ^(2)=4.000,P<0.05).Compared with the control group,the study group had higher Hp eradication rate,lower recurrence rate and incidence of adverse reactions,and the differences were statistically significant(all P<0.05).Conclusion The clinical efficacy of PPI triple therapy in children with Hp infection is satisfactory,which can effectively enhance the Hp eradication rate and reduce the incidence of recurrence and adverse drug reactions.

关 键 词：质子泵抑制剂 三联治疗 幽门螺杆菌感染 儿童 

分 类 号：R72[医药卫生—儿科]