奥硝唑和头孢曲松与多西环素联合疗法在盆腔炎治疗中的临床效果研究  

Clinical Efficacy of Ornidazole,Ceftriaxone and Doxycycline Combination Therapy in the Treatment of Pelvic Inflammatory Disease

作　　者：陈红梅 诸丽萍 CHEN Hongmei;ZHU Liping(Department of Gynecology,Nanjing Gaochun Hospital of Traditional Chinese Medicine,Nanjing 211300,Jiangsu,China)

机构地区：[1]南京市高淳中医院妇科,江苏南京211300

出　　处：《系统医学》2025年第5期171-174,共4页Systems Medicine

摘　　要：目的探讨奥硝唑、头孢曲松与多西环素联合疗法在盆腔炎治疗中对细胞因子及免疫功能的影响。方法回顾性选取2021年1月—2023年12月间在南京市高淳中医院就诊的80例盆腔炎患者的临床资料,根据治疗方式不同分为常规组和探究组,各40例。两组均进行常规基础治疗,常规组在此基础上应用头孢曲松与多西环素联合治疗,而探究组则采用奥硝唑、头孢曲松与多西环素联合疗法。比较两组细胞因子、免疫功能、治疗效果、不良反应发生率。结果治疗后,探究组细胞因子低于常规组,免疫功能优于常规组,差异有统计学意义(P均<0.05)。探究组治疗有效率为97.50%(39/40),高于常规组的80.00%(32/40),差异有统计学意义(χ^(2)=4.507,P<0.05)。治疗后,在恶心呕吐、食欲减退、头痛、失眠、皮疹、乏力眩晕方面,探究组不良反应发生率高于常规组,但差异无统计学意义(P>0.05)。结论奥硝唑、头孢曲松与多西环素联合疗法在盆腔炎治疗中能显著降低细胞因子水平,改善患者免疫功能,提高治疗有效率,且不增加不良反应,表明该联合疗法在盆腔炎治疗中具有潜在优势。Objective To explore the effects of combination therapy of ornidazole,ceftriaxone and doxycycline on cytokines and immune function in the treatment of pelvic inflammatory disease.Methods The clinical data of eighty patients with pelvic inflammatory disease who were treated in Nanjing Gaochun Hospital of Traditional Chinese Medicine from January 2021 to December 2023 were retrospectively selected.According to different treatment methods,they were divided into routine group and inquiry group,with forty cases in each group.Both groups were treated with conventional basic treatment.The conventional group was treated with ceftriaxone combined with doxycycline on this basis,while the inquiry group was treated with ornidazole,ceftriaxone combined with doxycycline.The cytokines,immune function,treatment efficiency and incidence of adverse reactions were compared between the two groups.Re⁃sults After treatment,the cytokines in the study group were lower than those in the conventional group,and the immune function was better than that in the conventional group,the differences were statistically significant(all P<0.05).The effective rate of treatment in the inquiry group was 97.50%(39/40).It was higher than 80.00%(32/40)of the conventional group,and the difference was statistically significant(χ^(2)=4.507,P<0.05).After treatment,in terms of nausea and vomiting,loss of appetite,headache,insomnia,rash,fatigue and vertigo,the incidence of adverse reactions in the inquiry group was higher than that in the conventional group,but the difference was not statistically significant(P>0.05).Conclusion Ornidazole,ceftriaxone and doxycycline combined therapy can significantly reduce the level of cytokines in the treatment of pelvic inflammatory disease,improve the immune function of patients,improve the effective rate of treatment,and does not increase adverse reactions,indicating that the combined therapy has potential advantages in the treatment of pelvic inflammatory disease.

关 键 词：奥硝唑 头孢曲松 多西环素 盆腔炎 细胞因子 免疫功能 不良反应 

分 类 号：R711[医药卫生—妇产科学]