下肢深静脉血栓形成患者血清炎症因子和凝血因子检测的临床意义  

Clinical significance of the detection of serum inflammation factors and coagulation factors in patients with lower extremity deep venous thrombosis

作　　者：云跃 任补元 Yun Yue;Ren Buyuan(Department of Vascular Surgery,Inner Mongolia Autonomous Region People's Hospital,Hohhot 010010,Inner Mongolia,China)

机构地区：[1]内蒙古自治区人民医院血管外科,内蒙古呼和浩特010010

出　　处：《血管与腔内血管外科杂志》2025年第3期323-327,共5页Journal of Vascular and Endovascular Surgery

基　　金：内蒙古自治区自然科学基金面上项目(2016MS0878)。

摘　　要：目的探讨下肢深静脉血栓(DVT)形成患者血清炎症因子和凝血因子检测的临床意义。方法选取2022年1月至2023年3月内蒙古自治区人民医院收治的下肢DVT患者作为DVT组,另选取同期无DVT的健康人群作为对照组,每组30例。比较两组研究对象血清炎症因子[白细胞介素(IL)-6、IL-18、C反应蛋白(CRP)]、凝血因子Ⅷ(FⅧ)和凝血因子Ⅸ(FⅨ)的表达水平。采用受试者工作特征(ROC)曲线评估各指标单独及联合检测对下肢DVT形成的诊断价值。结果DVT组的血浆IL-6、IL-18、CRP、FⅧ和FⅨ表达水平明显高于对照组,差异均有统计学意义(P﹤0.01)。DVT组患者定期复查血管超声,根据初次血栓变化情况分为血栓自溶组(n=15)、血栓不变组(n=10)和血栓新增组(n=5),其中,血栓新增组患者的血清炎症因子和凝血因子表达水平最高,其次是血栓不变组,最后是血栓自溶组,3组比较,差异有统计学意义(P﹤0.01)。ROC曲线分析结果显示,各指标对下肢DVT形成均具有一定的诊断价值,炎症因子与凝血因子相联合检测对下肢DVT形成的诊断灵敏度、特异度及约登指数均高于单一指标检测结果,诊断效能最高。结论下肢DVT形成患者血清IL-6、IL-18、CRP及凝血因子的表达水平均明显升高,联合检测对下肢DVT形成的诊断价值高。Objective To investigate the clinical significance of the detection of serum inflammation factors and coagulation factors in patients with lower extremity deep venous thrombosis(DVT).Method The lower extremity DVT patients admitted to Inner Mongolia Autonomous Region People's Hospital from January 2022 to March 2023 were selected as the DVT group,and the healthy individuals without DVT during the same period were selected as the control group,with 30 cases in each group.The expression levels of serum inflammatory factors[interleukin(IL)-6,IL-18,C-reactive protein(CRP)],coagulation factor Ⅷ(FⅧ)and coagulation factor Ⅸ(FVⅨ)between two groups of study subjects were compared.The receiver operator characteristic(ROC)curve was used to evaluate the diagnostic value of individual and combined detection of various indicators for the lower extremity DVT.Result The expression levels of serum IL-6,IL-18,CRP,FⅧ,and FVⅨin the DVT group were significantly higher than those in the control group,and the differences were statistically significant(P<0.01).The patients in the DVT group underwent regular vascular ultrasound examinations and were divided into three groups based on their initial thrombus changes:thrombus autolysis group(n=15),thrombus unchanged group(n=10)and thrombus addition group(n=5).Among them,the patients in thrombus addition group had the highest levels of serum inflammation and coagulation factor expression,followed by the thrombus unchanged group,and finally the thrombus autolysis group,the difference between the three groups was statistically significant(P<0.01).The ROC curve analysis results show that all indicators have certain diagnostic value for the formation of lower extremity DVT.The combined detection of inflammatory factors and coagulation factors has higher diagnostic sensitivity,specificity,and Jordan index for the formation of lower extremity DVT than the detection results of single inflammatory and coagulation factors,and the diagnostic efficiency was the highest.Conclusion The expres

关 键 词：下肢深静脉血栓形成 白细胞介素-6 白细胞介素-18 C反应蛋白 凝血因子 

分 类 号：R543[医药卫生—心血管疾病]