不同干预时间对结直肠癌患者术后下肢深静脉血栓的预防效果  

Preventive effect of different intervention times on postoperative lower extremitydeep vein thrombosis in patients with colorectal cancer

作　　者：刘学恩 徐国栋 胡奇志 李建超[3] Liu Xueen;Xu Guodong;Hu Qizhi;Li Jianchao(External Treatment Center,Beijing Hepingli Hospital,Beijing 100013,China;Department of General Surgery,Beijing Friendship Hospital Pinggu Campus,Capital Medical University,Beijing 101200,China;Department of General Surgery,Beijing Hepingli Hospital,Beijing 100013,China)

机构地区：[1]北京市和平里医院外治中心,北京100013 [2]首都医科大学附属北京友谊医院平谷医院普外科,北京101200 [3]北京市和平里医院普外科,北京100013

出　　处：《血管与腔内血管外科杂志》2025年第3期404-407,428,共5页Journal of Vascular and Endovascular Surgery

基　　金：北京中医药科技发展资金项目(JJ2018-61)。

摘　　要：目的比较不同干预时间对结直肠癌患者术后下肢深静脉血栓(DVT)的预防效果。方法收集2023年10月至2024年7月北京市和平里医院收治的184例结直肠癌患者的临床资料,根据启动针对下肢DVT预防措施的时间将患者分为早期组和对照组,每组92例。比较两组患者的手术相关指标和术后住院期间治疗结局,主要观察指标为术后住院期间下肢DVT的发生情况。结果早期组患者术中低体温的发生率低于对照组患者,手术持续时间短于对照组患者,差异均有统计学意义(P﹤0.05)。术后住院期间,早期组患者下肢DVT的发生率低于对照组患者,差异有统计学意义(P﹤0.05)。两组患者出院前凝血酶原时间、出院前活化部分凝血活酶时间以及术后住院期间出血的发生率比较,差异均无统计学意义(P﹥0.05)。结论早期干预可以明显降低结直肠癌患者术后住院期间下肢DVT的发生率,同时不增加出血风险,值得临床推广和进一步研究。Objective To investigate the preventive effect of different intervention times on postoperative lower extremity deep vein thrombosis(DVT)in patients with colorectal cancer.Method The clinical data of 184 cases colorectal cancer patients admitted to Beijing Hepingli Hospital from October 2023 to July 2024 were collected,and the patients were divided into early stage group and control group based on the time of initiating preventive measures for lower extremity DVT,with 92 cases in each group.The surgical related indicators and postoperative hospitalization treatment outcomes between two groups of patients were compared,the main observation indicator was the occurrence of lower extremity DVT during postoperative hospitalization.Result The incidence of hypothermia during surgery in the early stage group was lower than that in the control group,and the duration of surgery was shorter than that in the control group,the differences were statistically significant(P<0.05).During postoperative hospitalization,the incidence of lower extremity DVT in the early stage group of patients was lower than that in the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences in the prothrombin time before discharge,activated partial thromboplastin before discharge,and incidence of bleeding during postoperative hospitalization between the two groups of patients(P>0.05).Conclusion Early initiation of preventive interventions can significantly reduce the incidence of lower extremity DVT during postoperative hospitalization in patients with colorectal cancer,without increasing the risk of bleeding.It is worthy of clinical promotion and further research.

关 键 词：干预时间 早期干预 结直肠癌 手术 下肢深静脉血栓 预防 

分 类 号：R543[医药卫生—心血管疾病]