老龄人群骨再生中干细胞疗法的应用与挑战  

Application and Challenges of Stem Cell Therapy in Bone Regeneration in the Aging Population

作　　者：华信 林丹 Xin Hua;Dan Lin(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai;College of Medical Technology,Shanghai University of Medicine&Health Sciences,Shanghai)

机构地区：[1]上海理工大学健康科学与工程学院,上海 [2]上海健康医学院医学技术学院,上海

出　　处：《老龄化研究》2025年第2期108-113,共6页Aging Research

基　　金：国家自然科学基金(32201104)。

摘　　要：老龄人群骨再生面临诸多困境,如骨量流失、血管生成能力下降等,干细胞疗法应运而生。文章通过应用多种干细胞类型并优化技术流程,包括精准的采集、培养与移植环节,以及改善外部环境如调控免疫与炎症反应,同时遵循伦理法律规范,该疗法在一定程度上促进了老龄骨再生,表现为骨密度改善、愈合时间缩短等。但仍存在细胞质量不稳定、技术标准化不足等局限。未来需在细胞技术、流程规范、环境调控等多方面持续改进,并拓展多疾病联合治疗及跨学科合作应用方向,以提升疗效与安全性,推动老龄骨再生干细胞疗法的发展。Bone regeneration in the elderly population faces many difficulties,such as bone loss and angiogenesis capacity decline.Stem cell therapy arises at a historic moment.In this paper,through the applica-tion of a variety of stem cell types and optimize the technical process,including accurate acquisition,culture,and transplantation,and improve the external environment such as regulation of immune and inflammatory response,and follow the ethical law,the therapy to a certain extent,promote the aging bone regeneration,bone density improvement,the healing time shortened,etc.However,there are still limitations,such as unstable cell mass and insufficient technical standardization.In the fu-ture,it is necessary to continuously improve cell technology,process specification,environmental regulation,and other aspects,and expand the application direction of multi-disease combination therapy and interdisciplinary cooperation,so as to improve the efficacy and safety and promote the development of bone regenerative stem cell therapy for aging.

关 键 词：老龄人群 骨再生 干细胞疗法 技术流程 环境调控 

分 类 号：R681[医药卫生—骨科学]