地锦全草化学成分研究  

Chemical Constituents from the Whole Herb of Euphorbia humifusa

作　　者：戴鹏宇 黄锦豪 张凯惠 刘方乐 王美琪 祝晨蔯[1] 林朝展[1] DAI Peng-yu;HUANG Jin-hao;ZHANG Kai-hui;LIU Fang-le;WANG Mei-qi;ZHU Chen-chen;LIN Chao-zhan(School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China;The First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《中药材》2024年第7期1688-1693,共6页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金项目(82174266,82374616);广东省自然科学基金项目(2023A1515011027)。

摘　　要：目的:研究大戟科大戟属植物地锦Euphorbia humifusa Willd.的干燥全草的化学成分。方法:采用柱色谱等多种分离方法对地锦全草的甲醇提取物进行分离纯化,并运用现代波谱技术鉴定化合物结构。结果:从地锦全草中分离得到20个化合物,分别鉴定为:牡荆素鼠李糖苷(1)、鞣花酸-4′-O-(4″-O-没食子酰)-吡喃木糖苷(2)、橙皮素(3)、异鼠李素(4)、槲皮苷(5)、柚皮苷(6)、柚皮素(7)、牡荆素(8)、异槲皮苷(9)、槲皮素-3-O-(2″-O-没食子酰)-β-D-葡萄糖苷(10)、槲皮素-3-O-木糖-(1→2)-β-D-葡萄糖苷(11)、烟花苷(12)、大波斯菊苷(13)、3,3′-二甲氧基鞣花酸(14)、没食子酸(15)、没食子酸乙酯(16)、短叶苏木酚(17)、短叶苏木酚酸甲酯(18)、柯里拉京(19)、紫丁香苷(20)。结论:其中,化合物1~3为首次从大戟属植物中分离得到,化合物4~7为首次从该植物中分离得到。Objective:To study the chemical constituents of Euphorbia humifusa whole herb.Methods:The methanol extract of Eu-phorbia humifusa whole herb was isolated and purified by column chromatography,and the structures of the compounds were identified by modern spectroscopy.Results:Twenty compounds were isolated from Euphorbia humifusa whole herb and identified as vitexin-2′-O-rhamnoside(1),ellagic acid-4′-O-(4″-O-galloyl)-xylopyranoside(2),hesperetin(3),isorhamnetin(4),quercitrin(5),naringin(6),naringenin(7),vitexin(8),isoquercitrin(9),quercetin-3-O-(2″-O-galloyl)-β-D-glucoside(10),quercetin-3-O-xylopyranosyl-(1→2)-β-D-glucoside(11),nicotiflorin(12),cosmosiin(13),3,3′-di-O-methylellagic acid(14),gallic acid(15),ethyl gallate(16),brevifolin(17),methyl brevifolincarboxylate(18),corilagin(19),syringin(20),respectively.Conclusion:Among them,compounds 1 to 3 are iso-lated from Euphorbia genus for the first time,compounds 4 to 7 are isolated from Euphorbia humifusa for the first time.

关 键 词：地锦草 化学成分 黄酮 酚酸 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]