柴胡丹参饮联合四联疗法治疗肝胃气滞型慢性萎缩性胃炎伴Hp感染患者的疗效观察  

Observation on the therapeutic effect of Chaihu Danshen decoction combined with quadruple therapy in the treatment of patients with chronic atrophic gastritis of liver stomach qi stagnation type and Hp infection

作　　者：林媛超 黄慧恒 陈伟才 陈海钦 LIN Yuan-chao;HUANG Hui-heng;CHEN Wei-cai(Nanjing County Traditional Chinese Medicine Hospital,Zhangzhou 363600,China)

机构地区：[1]南靖县中医院,363600

出　　处：《中国现代药物应用》2025年第6期21-24,共4页Chinese Journal of Modern Drug Application

摘　　要：目的观察对肝胃气滞型慢性萎缩性胃炎(CAG)伴幽门螺杆菌(Hp)感染患者使用柴胡丹参饮联合四联疗法的疗效。方法60例肝胃气滞型CAG伴Hp感染患者,采用随机数字表法分为观察组和对照组,每组30例。对照组接受标准的抗Hp四联疗法治疗,观察组在对照组基础上给予柴胡丹参饮治疗。比较两组治疗前后中医证候积分、血清胃蛋白酶原(PG)Ⅰ、PGⅡ水平及临床疗效、Hp根除率、不良反应发生率。结果治疗后,观察组Hp根除率86.67%高于对照组的60.00%(P<0.05)。治疗后,两组胃胀、胃痛、胁肋胀痛、口苦口臭以及嗳气反酸积分均较本组治疗前降低,且观察组胃胀积分(0.83±0.45)分、胃痛积分(0.90±0.48)分、胁肋胀痛积分(1.06±0.44)分、口苦口臭积分(1.26±0.61)分、嗳气反酸积分(1.16±0.55)分明显低于对照组的(1.13±0.57)、(1.25±0.62)、(1.33±0.49)、(1.56±0.50)、(1.50±0.65)分(P<0.05)。治疗后,两组血清PGⅠ、PGⅡ水平均较本组治疗前改善,且观察组血清PGⅠ、PGⅡ水平分别为(110.56±26.50)、(21.53±9.92)ng/ml,明显优于对照组的(92.03±37.20)、(27.70±9.60)ng/ml(P<0.05)。观察组治疗总有效率86.67%高于对照组的60.00%(P<0.05)。治疗期间,两组均未出现头痛头晕、恶心、腹泻、过敏等不良反应。结论对于肝胃气滞型CAG伴Hp感染患者,柴胡丹参饮联合四联疗法较单纯四联疗法效果更佳,更能有效改善临床症状及血清PGⅠ、PGⅡ水平,促进胃黏膜修复,提高Hp根除率。Objective To observe the therapeutic effect of Chaihu Danshen decoction combined with quadruple therapy in the treatment of patients with chronic atrophic gastritis(CAG)of liver stomach qi stagnation type and Helicobacter pylori(Hp)infection.Methods 60 patients with chronic atrophic gastritis of liver stomach qi stagnation type and Hp infection were divided into an observation group and a control group according to random numerical table,with 30 cases in each group.The control group received standard anti Hp quadruple therapy,while the observation group received Chaihu Danshen decoction treatment on the basis of the control group.Comparison of traditional Chinese medicine syndrome score,serum pepsinogen(PG)Ⅰand PGⅡbefore and after treatment,Hp eradication rate,and incidence of adverse reactions between the two groups.Results After treatment,the Hp eradication rate of 86.67%in the observation group was higher than 60.00%in the control group(P<0.05).After treatment,the scores of stomach distension,stomachache,distending pain in hypochondrium,bitter mouth and bad breath,and belching and acid reflux in both groups were lower than those before treatment;in the observation group,the stomach distension score was(0.83±0.45)points,the stomachache score was(0.90±0.48)points,the distending pain in hypochondrium score was(1.06±0.44)points,the bitter mouth and bad breath score was(1.26±0.61)points,and the belching and acid reflux score was(1.16±0.55)points,which were significantly lower than(1.13±0.57),(1.25±0.62),(1.33±0.49),(1.56±0.50),and(1.50±0.65)points in the control group(P<0.05).After treatment,the PGⅠand PGⅡlevels in both groups were improved compared with before treatment;the PGⅠand PGⅡlevels in the observation group were(110.56±26.50)and(21.53±9.92)ng/ml,which were significantly better than(92.03±37.20)and(27.70±9.60)ng/ml in the control group (P<0.05). The total effective rate of 86.67% in the observation group was higher than 60.00% in the control group (P<0.05). During the treatment, no

关 键 词：柴胡丹参饮 幽门螺杆菌 四联疗法 慢性萎缩性胃炎 疗效 

分 类 号：R259[医药卫生—中西医结合]