NIPPV与NCPAP治疗早产儿呼吸窘迫综合征的临床疗效比较  

Comparison of clinical efficacy of NIPPV and NCPAP in the treatment of respiratory distress syndrome in premature infants

作　　者：李荣 LI Rong(Department of Pediatrics,Affiliated Hospital of Xuzhou Medical University,Xuzhou 221000,China)

机构地区：[1]徐州医科大学附属医院儿科,221000

出　　处：《中国现代药物应用》2025年第6期40-43,共4页Chinese Journal of Modern Drug Application

摘　　要：目的比较经鼻间歇正压通气(NIPPV)与经鼻持续气道正压通气(NCPAP)治疗早产儿呼吸窘迫综合征(RDS)的效果。方法70例新生儿重症监护室(NICU)胎龄28~34周的早产儿RDS患儿,采用随机数字表法分为NIPPV组和NCPAP组,各35例。NIPPV组患儿给予NIPPV辅助通气,NCPAP组患儿给予NCPAP辅助通气。比较两组患儿初始无创通气(NIV)成功率、总氧疗时间、住院时间、并发症发生情况及治疗前后血气分析指标。结果NIPPV组初始NIV成功率85.71%高于NCPAP组的62.86%,总氧疗时间(19.17±7.42)d、住院时间(24.77±6.25)d短于NCPAP组的(23.56±10.38)、(29.23±7.38)d,差异有统计学意义(P<0.05)。治疗后,两组pH、动脉血氧分压(PaO2)、氧合指数(OI)均高于本组治疗前,动脉血二氧化碳分压(PaCO_(2))低于本组治疗前,且NIPPV组pH(7.35±0.09)、PaO2(69.78±8.25)mm Hg(1 mm Hg=0.133 kPa)、OI(187.78±38.74)mm Hg均高于NCPAP组的(7.30±0.08)、(64.45±10.47)mm Hg、(162.45±36.55)mm Hg,PaCO_(2)(43.87±6.15)mm Hg低于NCPAP组的(47.23±6.34)mm Hg,差异有统计学意义(P<0.05)。两组肺气漏、鼻损伤、腹胀及早产儿支气管肺发育不良(BPD)发生率比较差异无统计学意义(P>0.05)。结论NIPPV可明显提高早产儿RDS患儿初始NIV成功率,改善氧合,缩短氧疗通气时间、住院时间,且不会增加并发症的发生。Objective To compare the effect of nasal intermittent positive pressure ventilation(NIPPV)and nasal continuous positive airway pressure(NCPAP)in the treatment of respiratory distress syndrome(RDS)in premature infants.Methods A total of 70 premature infants with RDS aged 28-34 weeks in neonatal intensive care unit(NICU)were divided into NIPPV group and NCPAP group by random numerical table,with 35 cases in each group.NIPPV group was given NIPPV assisted ventilation,and NCPAP group was given NCPAP assisted ventilation.The success rate of initial non-invasive ventilation(NIV),total duration of oxygen therapy,complications and blood gas analysis indexes before and after treatment were compared between the two groups.Results The success rate of initial NIV in NIPPV group was 85.71%,which was higher than 62.86%in NCPAP group;the total duration of oxygen therapy was(19.17±7.42)d,which was shorter than(23.56±10.38)d in NCPAP group;the difference was statistically significant(P<0.05).After treatment,pH,arterial partial oxygen pressure(PaO2)and oxygenation index(OI)in both groups were higher than those before treatment,and PaCO_(2) was lower than that before treatment;NIPPV group had pH of(7.35±0.09),PaO2 of(69.78±8.25)mm Hg(1 mm Hg=0.133 kPa)and OI of(187.78±38.74)mm Hg,which were higher than(7.30±0.08),(64.45±10.47)mm Hg and(162.45±36.55)mm Hg in NCPAP group;NIPPV group had a lower PaCO_(2) of(43.87±6.15)mm Hg than(47.23±6.34)mm Hg in NCPAP group;the difference was statistically significant(P<0.05).There was no significant difference in the incidence of pulmonary air leaks,nasal injury,abdominal distension and bronchopulmonary dysplasia(BPD)between the two groups(P>0.05).Conclusion NIPPV can significantly improve the success rate of initial NIV,improve oxygenation,shorten the duration of oxygen therapy and do not increase the occurrence of complications in premature infants with RDS.

关 键 词：经鼻间歇正压通气 经鼻持续气道正压通气 早产儿 呼吸窘迫综合征 

分 类 号：R722.6[医药卫生—儿科]