化学发光法与胶体金法检测甲肝、戊肝的临床价值研究  

Study on the clinical value of chemiluminescence and colloidal gold methods for the detection of viral hepatitis A and viral hepatitis E

作　　者：钟秀华 ZHONG Xiu-hua(Wuping County Center for Disease Control and Prevention,Longyan 364300,China)

机构地区：[1]福建省武平县疾病预防控制中心,364300

出　　处：《中国现代药物应用》2025年第6期55-58,共4页Chinese Journal of Modern Drug Application

摘　　要：目的比较化学发光法与胶体金法检测甲型病毒性肝炎(甲肝)和戊型病毒性肝炎(戊肝)的临床价值。方法选取确诊的甲肝患者30例和戊肝患者30例作为研究对象,均分别采用化学发光法和胶体金法对其血清样本进行检测。比较两种检测方法检测甲肝、戊肝患者的结果。结果化学发光法检测甲肝结果显示,28例诊断准确,1例误诊,1例漏诊,诊断准确率为93.33%;胶体金法检测甲肝结果显示,22例诊断准确,5例误诊,3例漏诊,诊断准确率为73.33%。化学发光法检测甲肝的诊断准确率高于胶体金法,差异具有统计学意义(P<0.05)。化学发光法检测戊肝结果显示,29例诊断准确,无误诊,1例漏诊,诊断准确率为96.67%;胶体金法检测戊肝结果显示,23例诊断准确,误诊3例,漏诊4例,诊断准确率为76.67%。化学发光法检测戊肝的诊断准确率高于胶体金法,差异具有统计学意义(P<0.05)。结论化学发光法相比胶体金法在检测甲肝和戊肝方面具有更高的准确性,更适合用于临床实验室的确诊检测。Objective To compare the clinical value of chemiluminescence and colloidal gold methods for the detection of viral hepatitis A and viral hepatitis E.Methods 30 patients with confirmed viral hepatitis A and 30 patients with viral hepatitis E were selected as study subjects,and their serum samples were tested by chemiluminescence and colloidal gold methods,respectively.The results of the two assays for viral hepatitis A and viral hepatitis E patients were compared.Results Chemiluminescence method for viral hepatitis A showed that 28 cases were diagnosed accurately,1 case was misdiagnosed and 1 case was missed,with a diagnostic accuracy of 93.33%;colloidal gold method for viral hepatitis A showed that 22 cases were diagnosed accurately,5 cases were misdiagnosed,3 cases were missed,and the diagnostic accuracy was 73.33%.The diagnostic accuracy of chemiluminescence method for viral hepatitis A was higher than that of colloidal gold method,and the difference was statistically significant(P<0.05).Chemiluminescence method for viral hepatitis E showed that 29 cases were diagnosed accurately,no misdiagnosis and 1 case was missed,the diagnostic accuracy was 96.67%;colloid gold method showed that 23 cases were diagnosed accurately,3 cases were misdiagnosed,4 cases were missed,and the diagnostic accuracy was 76.67%.The diagnostic accuracy of chemiluminescence method for viral hepatitis E was higher than that of colloidal gold method,and the difference was statistically significant(P<0.05).Conclusion Compared with colloidal gold method,chemiluminescence method has higher accuracy in detecting viral hepatitis A and viral hepatitis E,and is more suitable for confirmatory testing in clinical laboratories.

关 键 词：传染性疾病 甲型病毒性肝炎 戊型病毒性肝炎 免疫学检测 

分 类 号：R446.6[医药卫生—诊断学]