阴道冲洗配合双唑泰栓对滴虫阴道炎的治疗作用研究  

Study on the therapeutic effect of vaginal irrigation combined with metronidazole,clotrimazole and chlorhexidine acetate suppositories on trichomonas vaginitis

作　　者：邢夏青 秦真姿 XING Xia-qing;QIN Zhen-zi(Tengzhou City Guanqiao Town Health Center,Zaozhuang 277500,China)

机构地区：[1]滕州市官桥镇卫生院,277500 [2]滕州市龙阳镇卫生院,277500

出　　处：《中国现代药物应用》2025年第6期100-103,共4页Chinese Journal of Modern Drug Application

摘　　要：目的评价对滴虫阴道炎患者施以阴道冲洗、双唑泰栓联合治疗的疗效。方法66例滴虫阴道炎患者,按照抽签方法分为治疗组与对照组,每组33例。治疗组实施阴道冲洗、双唑泰栓联合治疗,对照组实施奥硝唑治疗。对比两组临床疗效、各项临床症状消失时间、炎性因子[白细胞介素(IL)-13、IL-8、IL-2]水平、不良反应发生率及生活质量。结果与对照组(75.76%)对比,治疗组治疗总有效率(96.97%)更高(P<0.05)。与对照组[(2.65±0.43)、(4.58±0.35)、(4.27±0.50)、(5.75±0.76)d]对比,治疗组白带异常、外阴瘙痒、排尿疼痛、腰腹疼痛消失时间[(1.50±0.21)、(2.42±0.35)、(2.18±0.40)、(3.40±0.62)d]更短(P<0.05)。治疗后,与对照组的(27.88±3.05)、(3.14±0.33)、(7.56±0.72)pg/ml对比,治疗组IL-13(22.00±2.35)pg/ml、IL-8(1.73±0.20)pg/ml、IL-2(6.35±0.61)pg/ml更低(P<0.05)。与对照组(21.21%)对比,治疗组不良反应发生率(3.03%)明显较低(P<0.05)。治疗后,与对照组对比,治疗组物质状态功能、心理功能、躯体功能、社会功能评分更高(P<0.05)。结论对滴虫阴道炎患者施以阴道冲洗、双唑泰栓联合治疗效果满意,不但有效性和安全性较高,还可缩短临床症状消失时间,减轻炎性因子水平,利于生活质量提升,建议推广。Objective To evaluate the therapeutic effect of vaginal irrigation combined with metronidazole,clotrimazole and chlorhexidine acetate suppositories on trichomonas vaginitis.Methods 66 patients with trichomonas vaginitis were divided into treatment group and control group according to the lottery method,with 33 cases in each group.The treatment group was treated with vaginal irrigation in combination with metronidazole, clotrimazole and chlorhexidine acetate suppositories on trichomonas vaginitis, and the control group was treated with ornidazole. The clinical efficacy, disappearance time of clinical symptoms, levels of inflammatory factors[ interleukin (IL)-13, IL-8, IL-2], incidence of adverse reactions and quality of life of the two groups were compared. Results The total effective rate of the treatment group (96.97%) was higher than that of the control group (75.76%) (P<0.05). Compared with the control group[ (2.65±0.43), (4.58±0.35), (4.27±0.50) and (5.75±0.76) d], the disappearance time of abnormal leucorrhea, vulva pruritus, urination pain, lumbar and abdominal pain[ (1.50±0.21), (2.42±0.35), (2.18±0.40) and (3.40±0.62) d] were shorter in the treatment group (P<0.05). After treatment, the treatment group had IL-13 of (22.00±2.35) pg/ml, IL-8 of (1.73±0.20) pg/ml and IL-2 of (6.35±0.61) pg/ml, which were lower than (27.88±3.05), (3.14±0.33) and (7.56±0.72) pg/ml in the control group (P<0.05). Compared with the control group (21.21%), the incidence of adverse reactions in the treatment group (3.03%) was significantly lower (P<0.05). After treatment, the scores of material status function, psychological function, physical function and social function in the treatment group were higher compared with the control group (P<0.05). Conclusion For patients with trichomonas vaginitis, vaginal irrigation in combination with metronidazole, clotrimazole and chlorhexidine acetate suppositories is satisfactory, which is not only effective and safe, but also can shorten the disappearance time of clinical sympt

关 键 词：滴虫阴道炎 双唑泰栓 阴道冲洗 炎性因子 生活质量 

分 类 号：R711.31[医药卫生—妇产科学]