二甲双胍治疗妊娠期糖尿病患者的临床效果分析  

Clinical effect analysis of metformin in the treatment of gestational diabetes mellitus

作　　者：田萍 宋颜玲 TIAN Ping;SONG Yan-ling(Tengzhou Dongguo Central Health Center,Zaozhuang 277533,China)

机构地区：[1]滕州市东郭中心卫生院,277533 [2]滕州市龙阳镇卫生院,277500

出　　处：《中国现代药物应用》2025年第6期111-114,共4页Chinese Journal of Modern Drug Application

摘　　要：目的分析妊娠期糖尿病患者开展二甲双胍治疗的临床疗效。方法选择妊娠期糖尿病患者78例为分析对象,按照抽签法分为对照组和治疗组,每组39例。对照组给予胰岛素治疗,治疗组在对照组基础上给予二甲双胍治疗。对比两组治疗前后的血糖指标、血清细胞因子及产妇不良妊娠结局、新生儿不良结局。结果治疗后,与对照组的(5.02±0.28)mmol/L、(6.52±0.45)%、(6.18±0.85)mmol/L、(2.80±0.36)对比,治疗组空腹血糖(3.91±0.16)mmol/L、糖化血红蛋白(5.53±1.54)%、餐后2 h血糖(5.50±0.53)mmol/L、胰岛素抵抗指数(2.30±0.28)明显更低(P<0.05);治疗组新生儿不良结局发生率7.69%低于对照组的28.21%(P<0.05);治疗组产妇不良妊娠结局发生率10.26%低于对照组的38.46%(P<0.05);治疗后,与对照组的(56.55±6.45)ng/ml、(49.27±8.56)mg/L、(20.47±4.58)μmol/L、(7.16±3.55)ng/ml对比,治疗组血管细胞粘附分子-1(50.88±5.74)ng/ml、视黄醇结合蛋白-4(40.26±6.30)mg/L、晚期氧化蛋白产物(15.58±6.55)μmol/L、Toll样受体4(4.41±1.68)ng/ml更低(P<0.05)。结论对妊娠期糖尿病患者开展二甲双胍治疗效果良好,利于血糖指标控制,可使母婴结局得以改善,优化血清细胞因子水平,建议推广。Objective To analyze the clinical efficacy of metformin in the treatment of patients with gestational diabetes mellitus.Methods 78 patients with gestational diabetes mellitus were selected as the analysis subjects and divided into control group and treatment group according to the lottery method,with 39 cases in each group.The control group was given insulin therapy,and the treatment group was given metformin therapy based on the control group.The blood glucose indicators and serum cytokines before and after treatment,adverse pregnancy outcomes and adverse neonatal outcomes were compared between the two groups.Results After treatment,the treatment group had fasting blood glucose of(3.91±0.16)mmol/L,glycosylated hemoglobin of(5.53±1.54)%,2 h postprandial blood glucose of(5.50±0.53)mmol/L,and insulin resistance index of(2.30±0.28),which were significantly lower than(5.02±0.28)mmol/L,(6.52±0.45)%,(6.18±0.85)mmol/L,and(2.80±0.36)in the control group(P<0.05).The incidence of adverse neonatal outcomes in the treatment group was 7.69%,which was lower than 28.21%in the control group(P<0.05).The incidence of adverse pregnancy outcome in the treatment group was 10.26%,which was lower than 38.46%in the control group(P<0.05).After treatment,the treatment group had vascular cell adhesion molecule-1 of(50.88±5.74)ng/ml,retinol-binding protein-4 of(40.26±6.3)mg/L,advanced oxidation protein products of(15.58±6.55)μmol/L,and toll-like receptor 4 of(4.41±1.68)ng/ml,which were lower than(56.55±6.45)ng/ml,(49.27±8.56)mg/L,(20.47±4.58)μmol/L,and(7.16±3.55)ng/ml in the control group(P<0.05).Conclusion Metformin treatment for patients with gestational diabetes mellitus has a good effect,which is conducive to the control of blood glucose indicators,and can improve the maternal and infant outcomes,optimize the level of serum cytokines.It is recommended to be promoted.

关 键 词：妊娠期糖尿病 二甲双胍 妊娠结局 血清细胞因子 

分 类 号：R714.256[医药卫生—妇产科学]