大承气汤联合基础治疗对脓毒症肺损伤患者的治疗效果  

Therapeutic effect of Dachengqi Decoction combined with basic therapy on patients with lung injury due to sepsis

作　　者：王雁 WANG Yan(Intensive Care Unit,Quanzhou Hospital of Traditional Chinese Medicine,Quanzhou 362000,China)

机构地区：[1]福建省泉州市中医院重症医学科,362000

出　　处：《中国现代药物应用》2025年第6期122-125,共4页Chinese Journal of Modern Drug Application

摘　　要：目的探讨脓毒症肺损伤患者采用大承气汤联合基础治疗的临床疗效。方法选择80例脓毒症肺损伤患者进行研究,通过随机数字表法分为观察组和对照组,各40例。对照组进行基础治疗,观察组进行大承气汤联合基础治疗。对比两组患者治疗前后炎症指标水平、肺损伤相关指标、中医证候积分、序贯器官衰竭估计(SOFA)评分、急性生理与慢性健康(APACHEⅡ)评分及预后性指标。结果治疗后,观察组C反应蛋白(CRP)(11.22±0.52)mg/L、白细胞介素-1(IL-1)(15.11±1.13)pg/ml、白细胞介素-6(IL-6)(57.32±9.43)pg/ml均低于对照组的(20.34±1.85)mg/L、(22.80±1.86)pg/ml、(72.11±9.32)pg/ml(P<0.05);观察组氧合指数(PO2/FiO2)(270.44±25.36)mm Hg(1 mm Hg=0.133 kPa)高于对照组的(256.11±21.63)mm Hg,肺泡-动脉血氧分压差[P(A-a)O2](63.44±8.40)mm Hg低于对照组的(85.85±8.60)mm Hg(P<0.05);观察组中医证候积分、SOFA评分、APACHEⅡ评分分别为(8.02±0.55)、(4.11±0.61)、(11.25±0.63)分,均低于对照组的(12.44±0.66)、(6.12±0.62)、(16.85±0.75)分(P<0.05)。与对照组(8.66±2.24)d对比,观察组机械通气时间(6.12±1.27)d较短(P<0.05);两组患者入住重症加强护理病房(ICU)时间对比无统计学意义(P>0.05)。结论脓毒症肺损伤患者在基础治疗的同时采用大承气汤治疗可将中医证候积分减少,改善病情和有关指标,炎症指标水平降低,提升临床疗效。Objective To explore clinical efficacy of Dachengqi Decoction combined with basic therapy on patients with lung injury due to sepsis.Methods A total of 80 patients with lung injury due to sepsis were selected for comparative study.The patients were divided into observation group and control group by random numerical table,with 40 cases in each group.The control group received basic treatment,and the observation group received Dachengqi Decoction combined with basic therapy.Comparison of levels of inflammatory factors,lung injury related indicators,traditional Chinese medicine syndrome score,sequential organ failure assessment(SOFA)scores,acute physiological and chronic health evaluationⅡ(APACHEⅡ)scores before and after treatment,and prognostic indicators between the two groups.Results After treatment,the observation group had C-reactive protein(CRP)of(11.22±0.52)mg/L,interleukin-1(IL-1)of(15.11±1.13)pg/ml,and interleukin-6(IL-6)of(57.32±9.43)pg/ml,which were lower than(20.34±1.85)mg/L,(22.80±1.86)pg/ml,and(72.11±9.32)pg/ml in the control group(P<0.05).The oxygenation index(PO2/FiO2)of(270.44±25.36)mm Hg(1 mm Hg=0.133 kPa)in the observation group was higher than(256.11±21.63)mm Hg in the control group;the alveolar-arterial oxygen pressure difference[P(A-a)O2]of(63.44±8.40)mm Hg in the observation group was lower than(85.85±8.60)mm Hg in the control group(P<0.05);the traditional Chinese medicine syndrome score,SOFA score and APACHEⅡscore in the observation group were(8.02±0.55),(4.11±0.61)and(11.25±0.63)points,which were lower than(12.44±0.66),(6.12±0.62)and(16.85±0.75)points in the control group(P<0.05).Compared with(8.66±2.24)d in the control group,the duration of mechanical ventilation of the observation group was shorter at(6.12±1.27)d(P<0.05).There was no significant difference in length of intensive care unit(ICU)stay between the two groups(P>0.05).Conclusion Dachengqi Decoction combined with basic therapy for patients with lung injury due to sepsis can reduce the traditional Chinese m

关 键 词：大承气汤 基础治疗 脓毒症肺损伤 临床疗效 炎症指标 中医证候积分 

分 类 号：R278[医药卫生—中医学]