心脏靶向药物递送策略的智能设计及研究进展  

Intelligent Design and Research Advances of Cardiac Targeted Drug Delivery Strategies

作　　者：葛苏蕾 陈艺珊 李剑 周建平[1] 程皓 丁杨[1] GE Sulei;CHEN Yishan;LI Jian;ZHOU Jianping;CHENG Hao;DING Yang(Department of Pharmaceutics&State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 211198,China;Jinling Pharmaceutical Company Limited,Nanjing 210038,China)

机构地区：[1]中国药科大学药剂系,多靶标天然药物全国重点实验室,南京211198 [2]金陵药业股份有限公司,南京210038

出　　处：《中国现代应用药学》2025年第5期689-696,共8页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(82372113,82404565);国家高层次青年人才项目;江苏省杰出青年基金项目(BK20240096);江苏省自然科学基金青年项目(BK20231018);中国博士后科学基金面上项目(2023M733892)。

摘　　要：心脏疾病治疗药物的临床疗效提升,严重受限于药物的非特异性分布。本综述系统评述了心脏靶向药物递送系统,重点围绕仿生心脏天然修复途径、识别心肌生物标志、借助病灶血管增强渗透和滞留效应、响应病灶特殊微环境等智能载体设计策略。此外,还探讨了局部给药方式与多种心脏靶向策略联合应用,以促进药物跨生理屏障的心脏病灶浓集给药。基于此,本综述深入剖析了心脏靶向递送系统面临的挑战,并展望了其临床转化前景。通过系统阐述心脏靶向策略的智能设计和应用前景,旨在为心脏靶向递药的研究发展提供参考。The clinical efficacy of therapeutic drugs for cardiovascular diseases was severely limited by the nonspecific distribution of the drugs.The present review systematically summarized cardiac-targeted drug delivery systems,focusing on intelligent design strategies that mimicked endogenous cardiac repair pathways,recognized myocardial biomarkers,leveraged the EPR effect of lesion vessels,and responded to the unique microenvironment of lesions.Moreover,the review discussed local drug administration methods and combinative strategies of various cardiac targeting to promote concentrated drug delivery at cardiac lesion sites across physiological barriers.Accordingly,the present review provided an in-depth analysis of the challenges faced by cardiac-targeted delivery systems and looked forward to their clinical transformation prospects.Reviewing the intelligent design and application prospects of cardiac-targeted strategies aimed to provide important references for the research and development of cardiac-targeted drug delivery.

关 键 词：心脏疾病 靶向递药策略 心脏修复治疗 心脏局部给药 研究进展 

分 类 号：R943[医药卫生—药剂学]