层次分析联合熵权法的艾叶挥发油质量标志物研究  

Research on Q-Markers of Volatile Oil from Artemisiae Argyi Folium by Analytic Hierarchy Process Combined Entropy Weight Method

作　　者：王云龙 陈盛虎 陈诗 鲁灵玉 万松彤 葛月宾[1] WANG Yunlong;CHEN Shenghu;CHEN Shi;LU Lingyu;WAN Songtong;GE Yuebin(School of Pharmaceutical Science,South-Central Minzu University,Wuhan 430074,China;Fruit and Tea Office of Hubei Province,Wuhan 430071,China;Service Center for Agricultural Industry,Changyang Tujiazu Autonomous County,Yichang 443500,China)

机构地区：[1]中南民族大学药学院,武汉430074 [2]湖北省果茶办公室,武汉430071 [3]长阳土家族自治县农业产业服务中心,湖北宜昌443500

出　　处：《中国现代应用药学》2025年第5期743-753,共11页Chinese Journal of Modern Applied Pharmacy

基　　金：湖北省中医药管理局中医药科研项目(ZY2023Z022)。

摘　　要：目的采用层次分析法(analytic hierarchy process,AHP)-熵权法(entropy weight method,EWM),结合网络药理学,研究艾叶挥发油潜在的质量标志物,为其质量控制提供参考。方法从中药质量标志物的基本原则出发,应用AHP-EWM对艾叶挥发油的质量标志物进行量化辨识,AHP法应用于要素层的权重分析,EWM法分析各要素层下控制层的权重分析。控制层中的有效性指标根据网络药理学中各成分对应的靶点数、通路数与支持文献选取;可测性指标来源于GC-MS中的各成分平均含量、相对标准偏差及相关文献;特有性指标为含有该化合物的植物数。结果以建立的中药质量标志物量化辨识体系为筛选条件,共遴选龙脑、β-石竹烯、桉油精、丁香酚、左旋樟脑、α-蒎烯、大根香叶烯D、β-蒎烯、水合桧烯、萜品烯-4-醇、α-侧柏酮等11种成分作为艾叶挥发油的质量标志物。结论基于质量标志物的有效性、可测性、特有性,确定的11种质量标志物能较全面反映艾叶挥发油的品质,为艾叶挥发油的质量控制提供参考依据。OBJECTIVE To study the potential quality markers(Q-markers)of volatile oil from Artemisiae Argyi Folium(VOAA)by the analytic hierarchy process(AHP)-entropy weight method(EWM)combined with network pharmacology,so as to provide reference for the quality control of VOAA.METHODS According to the basic principles of Q-markers of traditional Chinese medicine,the AHP and EWM was used to identify and quantify the Q-markers of VOAA.The former was applied to the weight analysis of the element layer,and the latter was to the weight analysis of the control layer under each element layer.The efficiency index in the control layer was selected according to the number of targets,pathway numbers and supporting literature corresponding to each component in network pharmacology.The measurability index was derived from the average content,coefficient of variation and related literature of each component in GC-MS.The endemic index was the number of plants containing the compound.RESULTS Using the established quantitative identification system for traditional Chinese medicine Q-markers as the screening criteria,eleven components,including dipterocarp,β-caryophyllene,eugenol,L-camphor,α-pinene,genanthene,genanthene D,β-pinene,juniperene hydrate,4-terpineol andα-thujone,were successfully chosen as Q-markers of VOAA.CONCLUSION Based on the effectiveness,quantifiability and uniqueness of Q-marker,the 11 quality markers identified can fully reflect the quality of mugwort leaf oil,and provide a reference for the quality control of VOAA.

关 键 词：艾叶挥发油 质量标志物 量化辨识 质量评价 层次分析 熵权法 

分 类 号：R284.1[医药卫生—中药学] R917.101[医药卫生—中医学]