中药有效成分治疗心肌缺血损伤的研究进展  

Research Progress on the Treatment of Myocardial Ischemia Injury with Active Ingredients of Traditional Chinese Medicine

作　　者：周娇 王长福 曾元宁 王秋红[1,2] ZHOU Jiao;WANG Changfu;ZENG Yuanning;WANG Qiuhong(Key Laboratory of Basic and Application Research of Beiyao,Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China;School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室,哈尔滨150040 [2]广东药科大学中药学院,广州510006

出　　处：《中国现代应用药学》2025年第5期820-829,共10页Chinese Journal of Modern Applied Pharmacy

基　　金：国家重点研发计划项目(2018YFC1707100);国家自然科学基金面上项目(81773904);国家“重大新药创制”科技重大专项(2018ZX09731-001);广东省中医药局科研项目(51348459)。

摘　　要：心血管疾病是目前中国居民因疾病死亡的首要原因,心肌缺血是许多心血管疾病的常见诱因。诸多研究表明中药因其多成分、多靶点、多途径的特点对心肌缺血损伤的治疗具有独特的优势。本文通过检索近年来国内外中药抗心肌缺血损伤的相关文献,系统综述了中药有效成分治疗心肌缺血损伤的作用机制,其中包括萜类、黄酮类、皂苷类、生物碱类、多酚类、挥发油等化合物,主要通过抗氧化应激损伤、抑制炎症反应、改善能量代谢、抑制细胞凋亡和激活自噬等发挥作用,旨在为心肌缺血损伤的治疗和临床药物研发提供参考和依据。Cardiovascular disease is the primary cause of death among Chinese residents,and myocardial ischemia is a common cause of many cardiovascular diseases.Many studies have shown that traditional Chinese medicine(TCM)has unique advantages in the treatment of myocardial ischemia due to its multi-component,multi-target and multi-pathway characteristics.By searching the relevant literature of TCM against myocardial ischemia injury at home and abroad in recent years,the paper systematically reviewed the research on the mechanism of action of TCM active ingredients in the treatment of myocardial ischemic injury,including terpenoids,flavonoids,saponins,alkaloids,polyphenols,volatile oils and other compounds,which mainly played a role in antioxidant stress damage,inhibition of inflammatory response,improvement of energy metabolism,inhibition of apoptosis and activation of autophagy,aiming to provide reference and basis for the treatment of myocardial ischemia injury and clinical drug development.

关 键 词：中药 有效成分 心肌缺血损伤 作用机制 研究进展 

分 类 号：R285.6[医药卫生—中药学]