格列美脲联合二甲双胍或阿卡波糖治疗对初诊2型糖尿病患者血糖及血脂水平的影响对比  

Effect of Glimepiide Combined with Metformin or Acarbose on Blood Glucose and Lipid Levels in Newly Diagnosed Patients with Type 2 Diabetes Mellitus

作　　者：王亚如 李艳华[1] WANG Yaru;LI Yanhua(Department of Endocrinology,Taierzhuang District People’s Hospital of Zaozhuang City,Zaozhuang 277400,China)

机构地区：[1]枣庄市台儿庄区人民医院内分泌科,山东枣庄277400

出　　处：《反射疗法与康复医学》2025年第7期160-163,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨格列美脲联合二甲双胍或阿卡波糖在初诊2型糖尿病患者中的应用效果。方法选取2023年7月—2024年7月枣庄市台儿庄区人民医院收治的102例初诊2型糖尿病患者为研究对象,按随机数字表法将其分为对照组和观察组,各51例。对照组采用格列美脲联合阿卡波糖治疗,观察组采用格列美脲联合二甲双胍治疗,两组均持续治疗3个月。比较两组的临床疗效、血糖水平、血脂水平及不良反应发生情况。结果观察组治疗总有效率为94.12%,高于对照组的80.39%,差异有统计学意义(P<0.05)。治疗后,观察组空腹血糖、餐后2 h血糖、糖化血红蛋白、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在初诊2型糖尿病患者治疗中,格列美脲联合二甲双胍的疗效优于格列美脲联合阿卡波糖,其可控制血糖水平,调节脂质代谢,且安全性较好。Objective To investigate the effect of glimepiride combined with metformin or acarbose in patients with newly diagnosed type 2 diabetes mellitus.Methods A total of 102 patients with newly diagnosed type 2 diabetes mellitus who were admitted to Taierzhuang District People’s Hospital of Zaozhuang City from July 2023 to July 2024 were selected as the research objects,according to the random number table method,they were divided into a control group and an observation group,with 51 cases in each group.The control group was treated with glimepiride combined with acarbose,and the observation group was treated with glimepiride combined with metformin,both groups were treated for 3 months.The clinical efficacy,blood glucose level,blood lipid level and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of the observation group was 94.12%,which was higher than 80.39%of the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of fasting blood glucose,2-hour postprandial blood glucose,glycosylated hemoglobin,total cholesterol,triglyceride,and low-density lipoprotein cholesterol in the observation group were lower than those in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of newly diagnosed type 2 diabetes patients,the efficacy of glimepiride combined with metformin is better than that of glimepiride combined with acarbose.It can control blood glucose level,regulate lipid metabolism,and has good safety.

关 键 词：2型糖尿病 格列美脲 二甲双胍 阿卡波糖 血糖 血脂 

分 类 号：R587.1[医药卫生—内分泌]