丹参酮对细胞信号通路调控作用的研究进展  

Research Advances in the Regulatory Effects of Tanshinone on Cell Signaling Pathways

作　　者：郭宁宁 苏力德 斯日古冷 那仁满都拉 GUO Ningning;SULIDE;SIRIGULENG;NARANMANDURA Hua(Inner Mongolia Medical University,College of Pharmaceutical Sciences,Hohhot 010110,China;Inner Mongolia Medical University,College of Mongolia Medical,Hohhot 010110,China;International Mongolia Hospital of Inner Mongolia,Hohhot 010000,China;School of Medicine,Zhejiang University,Hangzhou 310058,China)

机构地区：[1]内蒙古医科大学药学院,呼和浩特010110 [2]内蒙古医科大学蒙医药学院,呼和浩特010110 [3]内蒙古自治区国际蒙医医院,呼和浩特010000 [4]浙江大学医学院,杭州310058

出　　处：《中国现代应用药学》2025年第4期665-678,共14页Chinese Journal of Modern Applied Pharmacy

基　　金：国家自然科学基金项目(82170143、82370191);浙江省自然科学基金项目(LD22H310005)。

摘　　要：丹参酮是从中国传统中药材丹参中提取的一类脂溶性生物活性成分,其主要单体成分有丹参酮I、丹参酮ⅡA、二氢丹参酮、3-羟基丹参酮、隐丹参酮等,这些单体具有抗菌抗炎、抗肿瘤、心血管保护等多种药理作用。多项研究表明,丹参酮可能是通过调节几种细胞信号转导通路或靶向调控疾病发生发展过程中的关键驱动分子来发挥其药理活性的,本文主要通过对近几年丹参酮各类单体的药理作用机制研究进行全面总结,为丹参酮类药物制剂的后续研究及临床应用提供理论依据。Tanshinone is a class of lipophilic bioactive compounds extracted from the traditional Chinese herb Salvia miltiorrhiza,primarily consists of monosubstituted compounds such as tanshinone I,tanshinone IIA,dihydrotanshinone,3-hydroxytanshinone,and cryptotanshinone,et al.These monosubstituted compounds exhibit diverse pharmacological effects including antibacterial and anti-inflammatory activities,anti-tumor effects,and cardiovascular protection.Multiple studies have suggested that tanshinone may exert its pharmacological activity by modulating various cell signaling pathways or targeting key drivers of disease progression.This review aims to comprehensively summarize the pharmacological mechanisms of action of various monosubstituted compounds of tanshinone in recent years,thereby providing theoretical support for subsequent research and clinical application of tanshinone-based drugs.

关 键 词：丹参酮 信号通路 靶向调控 药理作用 

分 类 号：R966[医药卫生—药理学]