辐状肋柱花化学成分的研究  

Chemical Constituents of Lomatogonium rotatum

作　　者：李亚荣 赵兰君 杨安南 李志峰 李艳 王琦 LI Ya-rong;ZHAO Lan-jun;YANG An-nan;LI Zhi-feng;LI Yan;WANG Qi(College of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Nanchang Key Laboratory of Active Ingredients of Traditional Chinese Medicine and Natural Medicine,Nanchang 330004,China;State Key Laboratory of Innovative Drugs and High Efficiency and Energy Saving Pharmaceutical Equipment,Nanchang 330004,China)

机构地区：[1]江西中医药大学药学院,江西南昌330004 [2]南昌市中药与天然药物活性成分研究重点实验室,江西南昌330004 [3]创新药物与高效节能降耗制药设备国家重点实验室,江西南昌330004

出　　处：《中药材》2024年第9期2225-2232,共8页Journal of Chinese Medicinal Materials

基　　金：江西省教育厅科学技术研究项目(GJJ211231);江西省自然科学基金项目(20224ACB206047)。

摘　　要：目的:研究龙胆科肋柱花属植物辐状肋柱花Lomatogonium rotatum(L.) Fries ex Nym.的化学成分。方法:利用多种柱色谱方法和制备液相色谱对辐状肋柱花的醇提物进行分离纯化,并运用波谱技术鉴定化合物结构。结果:从辐状肋柱花中分离得到30个化合物,分别鉴定为:木犀草素(1)、6-hydroxyluteolin(2)、海波拉亭-7-O-β-D-吡喃葡萄糖苷(3)、三粒小麦黄酮(4)、1-羟基-3,7,8-三甲氧基(口山)酮(5)、木犀草素-3′-O-β-D-吡喃葡萄糖苷(6)、luteolin-4′-O-β-D-glucopyranoside(7)、1,3,5,8-四羟基-5,6,7,8-4H-(口山)酮(8)、1,3,5-三羟基(口山)酮(9)、isoscutellarein-7-O-β-D-glucopyranoside(10)、含珠藓黄酮(11)、dennettine(12)、当药黄素(13)、tetrasweroside A(14)、1-羟基-3,5,8-三甲氧基(口山)酮(15)、1,3,8-三羟基-2,5-二甲氧基(口山)酮(16)、山柰酚-3-O-β-D-刺槐双糖苷(17)、对羟基苯甲醛(18)、东莨菪素(19)、5,3′,4′-三羟基-7-甲氧基黄酮(20)、corymbiferin-3-O-β-D-glucopyranoside(21)、木犀草素-5-O-β-D-葡萄糖苷(22)、木犀草素-7-O-葡萄糖苷(23)、异牡荆苷(24)、carinoside C(25)、syringaresinol mono-β-D-glucoside(26)、6-O-[β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranosyl]-1,4,8-trimethoxyxanthone(27)、carinoside B(28)、香草醛(29)、对羟基苯乙酮(30)。结论:其中,化合物2、6、9~12、17、18、20为首次从肋柱花属植物中分离得到,化合物14、16、25、28~30为首次从辐状肋柱花中分离得到。Objective:To study the chemical constituents of Lomatogonium rotatum.Methods:The compounds from the ethanol ex-tract of Lomatogonium rotatum were isolated and purified by column chromatography and preparative liquid chromatography,the struc-tures of the compounds were identified by spectroscopic technique.Results:Thirty compounds were isolated from Lomatogonium rotatum and identified as luteolin(1),6-hydroxyluteolin(2),hypolaetin-7-O-β-D-glucopyranoside(3),tricetin(4),1-hydroxyl-3,7,8-trime-thoxyxanthone(5),luteolin-3′-O-β-D-glucopyranoside(6),luteolin-4′-O-β-D-glucopyranoside(7),1,3,5,8-tetrahydroxy-5,6,7,8-4H-xanthone(8),1,3,5-trihydroxyxanthone(9),isoscutellarein-7-O-β-D-glucopyranoside(10),philonotisflavone(11),dennettine(12),swertisin(13),tetrasweroside A(14),1-hydroxyl-3,5,8-trimethoxyxanthone(15),1,3,8-trihydroxy-2,5-dimethoxyxanthone(16),kaempferol-3-O-β-D-robinobioside(17),p-hydroxybenzaldehyde(18),scopoletin(19),5,3′,4′-trihydroxy-7-methoxyflavone(20),corymbiferin-3-O-β-D-glucopyranoside(21),luteolin-5-O-β-D-glucoside(22),luteolin-7-O-glucoside(23),isovitexin(24),carinoside C(25),syringaresinol mono-β-D-glucoside(26),6-O-[β-D-xylopyranosyl-(1→6)-O-β-D-glucopyranosyl]-1,4,8-trimethoxyxanthone(27),carinoside B(28),vanillin(29),p-hydroxyacetophenone(30),respectively.Conclusion:Among them,compounds 2,6,9 to 12,17,18,20 are isolated from Pleurostyla for the first time,compounds 14,16,25,28 to 30 are isolated from Lomatogonium rotatum for the first time.

关 键 词：龙胆科 辐状肋柱花 化学成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]