肝爽颗粒联合富马酸丙酚替诺福韦治疗对慢性乙型肝炎患者HBsAg血清学转换率及肝功能的影响  

Effect of Ganshuang Granules Combined with Tenofovir Alafenamide Fumarate on HBsAg Seroconversion Rate and Liver Function in Patients with Chronic Hepatitis B

作　　者：侯永婉 任轺 肖敏恒 HOU Yongwan;REN Yu;XIAO Minheng(Department of Infection,Panzhou People’s Hospital,Liupanshui 553000,China)

机构地区：[1]盘州市人民医院感染科,贵州六盘水553000

出　　处：《反射疗法与康复医学》2025年第1期28-30,38,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨肝爽颗粒联合富马酸丙酚替诺福韦治疗对慢性乙型肝炎(CHB)患者乙肝表面抗原(HBsAg)血清学转换率及肝功能的影响。方法选取盘州市人民医院2022年2月—2023年3月收治100例CHB患者为研究对象,按随机数字表法将其分为对照组和观察组,各50例。对照组采用富马酸丙酚替诺福韦治疗,观察组采用肝爽颗粒联合富马酸丙酚替诺福韦治疗。对比两组的临床疗效、HBsAg血清学转换率、肝功能及不良反应发生情况。结果观察组治疗总有效率为98.00%,HBsAg转换率为60.00%,均高于对照组的84.00%、30.00%,组间差异有统计学意义(P<0.05)。治疗后,观察组丙氨酸氨基转移酶水平为(64.21±11.94)U/L,天门冬氨酸氨基转氨酶水平为(59.76±12.37)U/L,谷氨酰转肽酶水平为(23.56±6.23)μmol/L,均低于对照组的(94.36±18.46)U/L、(86.35±19.56)U/L、(37.23±9.82)μmol/L,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论CHB患者应用肝爽颗粒联合富马酸丙酚替诺福韦治疗的疗效显著,可有效提升HBsAg血清学转换率,改善肝功能,且治疗方案安全可靠。Objective To explore the effect of Ganshuang granule combined with tenofovir alafenamide fumarate on the hepatitis B surface antigen(HBsAg)seroconversion rate and liver function in patients with chronic hepatitis B(CHB).Methods Selection of 100 CHB patients admitted to Panzhou People's Hospital from February 2022 to March 2023 as the research subjects,they were randomly divided into a control group and an observation group,with 50 cases in each group,using a random number table method.The control group was treated with tenofovir alafenamide fumarate,while the observation group was treated with Ganshuang granules combined with tenofovir alafenamide fumarate.Compare the clinical efficacy,HBsAg seroconversion rate,liver function,and occurrence of adverse reactions between two groups.Results The total effective rate of the observation group was 98.00%,and the HBsAg conversion rate was 60.00%,which were higher than 84.00%and 30.00%of the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the levels of alanine aminotransferase,aspartate aminotransferase,and glutamyl transpeptidase in the observation group were(64.21±11.94)U/L,(59.76±12.37)U/L,and(23.56±6.23)μmol/L,respectively,which were lower than(94.36±18.46)U/L,(86.35±19.56)U/L,and(37.23±9.82)μmol/L in the control group,and the differences between the groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The application of Ganshuang granules combined with tenofovir alafenamide fumarate in CHB patients has significant therapeutic effects,effectively improves HBsAg seroconversion rate,improves liver function,and the treatment plan is safe and reliable.

关 键 词：慢性乙型肝炎 肝爽颗粒 富马酸丙酚替诺福韦 乙肝表面抗原血清学转换率 肝功能 

分 类 号：R512.6[医药卫生—内科学]