防己黄芪汤加减联合常规西药对风水相搏型肾病综合征顽固性水肿患者肾功能及炎症指标的影响  

Effect of Modified Fangji Huangqi Decoction Combined with Conventional Western Medicine on Renal Function and Inflammatory Indicators of Patients with Refractory Edema of Nephrotic Syndrome of the Type of Wind-Water Attacking Each Other

作　　者：刘天成 LIU Tiancheng(Department of Nephrology,Dandong Traditional Chinese Medicine Hospital,Dandong 118000,China)

机构地区：[1]丹东市中医院肾内科,辽宁丹东118000

出　　处：《反射疗法与康复医学》2025年第2期22-25,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨风水相搏型肾病综合征(NS)顽固性水肿患者予以防己黄芪汤加减联合常规西药治疗对其肾功能、炎症指标的影响。方法选取2022年6月—2024年5月丹东市中医院收治的84例风水相搏型NS顽固性水肿患者为研究对象,按随机数字表法将其分为对照组和观察组,每组42例。对照组采用常规西药治疗,观察组在对照组的基础上采用防己黄芪汤加减治疗,两组均持续治疗1个月。比较两组的临床疗效、肾功能、炎症指标、不良反应发生情况。结果观察组治疗总有效率为95.24%,高于对照组的80.95%,差异有统计学意义(P<0.05)。治疗后,观察组血肌酐、血尿素氮、24h尿蛋白水平均低于对照组,白蛋白水平高于对照组,组间差异有统计学意义(P<0.05);观察组白细胞介素-6、白细胞介素-17、肿瘤坏死因子-α水平均低于对照组,组间差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论防己黄芪汤加减联合常规西药治疗风水相搏型NS顽固性水肿患者效果显著,可减轻机体炎症反应,改善肾功能,且安全性高。Objective To explore the effects of modified Fangji Huangqi Decoction combined with conventional Western medicine treatment on renal function and inflammatory indexes in patients with refractory edema of nephrotic syndrome(NS)of the type of wind-water attacking each other.Methods A total of 84 patients with refractory edema of NS of the type of wind-water attacking each other admitted to Dandong Traditional Chinese Medicine Hospital from June 2022 to May 2024 were selected as the research objects.They were divided into a control group and an observation group according to the random number table method,with 42 patients in each group.The control group was treated with conventional Western medicine,and the observation group was treated with modified Fangji Huangqi Decoction on the basis of the control group,both groups were continuously treated for 1 month.The clinical efficacy,renal function,inflammatory indicators,and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was 95.24%,which was higher than 80.95%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of serum creatinine,blood urea nitrogen,and 24-hour urinary protein in the observation group were all lower than those in the control group,while the level of albumin was higher than that in the control group,and the differences between the two groups were statistically significant(P<0.05);the levels of interleukin-6,interleukin-17,and tumor necrosis factor-αin the observation group were all lower than those in the control group,and the differences between the two groups were statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of patients with refractory edema of NS of the type of wind-water attacking each other with modified Fangji Huangqi Decoction combined with conventional Western medicin

关 键 词：肾病综合征 顽固性水肿 风水相搏型 防己黄芪汤加减 常规西药 肾功能 炎症指标 

分 类 号：R692[医药卫生—泌尿科学]