美托洛尔联合苯磺酸氨氯地平治疗对高血压合并慢性心力衰竭患者心功能的影响  

Effect of Metoprolol Combined with Amlodipine Besylate on Cardiac Function in Patients with Hypertension Complicated with Chronic Heart Failure

作　　者：高松 阚宏亮 GAO Song;KAN Hongliang(Department of Pharmacy,Dongying Traditional Chinese Medicine Hospital,Dongying 257000,China;Department of No.1 Heart Disease,Dongying Traditional Chinese Medicine Hospital,Dongying 257000,China)

机构地区：[1]东营市中医院药剂科,山东东营257000 [2]东营市中医院心病一科,山东东营257000

出　　处：《反射疗法与康复医学》2025年第2期89-92,共4页Reflexology And Rehabilitation Medicine

摘　　要：目的探讨美托洛尔联合苯磺酸氨氯地平治疗对高血压合并慢性心力衰竭患者的影响。方法选择2022年2月—2024年4月东营市中医院收治的144例高血压合并慢性心力衰竭患者为研究对象,采用随机数字表法将其分为对照组和观察组,各72例。对照组采用美托洛尔治疗,观察组采用美托洛尔联合苯磺酸氨氯地平治疗。对比两组的血压变异性、心功能、血液流变学指标、不良反应发生情况。结果治疗后,两组日间舒张压标准差、日间收缩压标准差、夜间舒张压标准差、夜间收缩压均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05);两组左心室射血分数均高于治疗前,且观察组高于对照组,两组左心室舒张末期内径、左心室收缩末期内径均短于治疗前,且观察组均短于对照组,差异有统计学意义(P<0.05);两组纤维蛋白原、血细胞比容、全血高切黏度、全血低切黏度、血浆黏度水平均低于治疗前,且观察组均低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论在高血压合并慢性心力衰竭患者中采用美托洛尔联合苯磺酸氨氯地平治疗,可改善患者的血压水平、心功能、血液流变学指标,且安全可靠。Objective Exploring the effect of metoprolol combined with amlodipine besylate on patients with hypertension complicated with chronic heart failure.Methods A total of 144 patients with hypertension complicated with chronic heart failure admitted to Dongying Traditional Chinese Medicine Hospital from February 2022 to April 2024 were selected as the research subjects,using a random number table method,they were divided into a control group and an observation group,with 72 cases in each group.The control group was treated with metoprolol,while the observation group was treated with metoprolol combined with amlodipine besylate.Compare the blood pressure variability,cardiac function,hemorheological indicators,and occurrence of adverse reactions between two groups.Results After treatment,the daytime diastolic blood pressure standard deviation,daytime systolic blood pressure standard deviation,nighttime diastolic blood pressure standard deviation,and nighttime systolic blood pressure standard deviation in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05);the left ventricular ejection fraction in both groups were higher than those before treatment,and the observation group was higher than that in the control group,the left ventricular end diastolic diameter and left ventricular end systolic diameter in both groups were shorter than those before treatment,and the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05);the levels of fibrinogen,hematocrit,whole blood high shear viscosity,whole blood low shear viscosity,and plasma viscosity in both groups were lower than those before treatment,and the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Comparison of incidence of adverse reactions between two groups,the difference was not statistically significant(P>0.05).Conclus

关 键 词：高血压 慢性心力衰竭 美托洛尔 苯磺酸氨氯地平 心功能 血液流变学指标 

分 类 号：R544.1[医药卫生—心血管疾病]