无催化剂、无溶剂下硅醚的绿色合成新方法  

New method for the catalyst‑and solvent‑free green synthesis of silyl ether

作　　者：于静 闫晓雨 牛双林 王喻璇 马献涛 YU Jing;YAN Xiaoyu;NIU Shuanglin;WANG Yuxuan;MA Xiantao(College of Chemistry and Chemical Engineering/Green Catalysis&Synthesis Key Laboratory of Xinyang City,Xinyang Normal University,Xinyang 464000,China)

机构地区：[1]信阳师范大学化学化工学院/信阳市绿色催化与合成重点实验室,河南信阳464000

出　　处：《信阳师范大学学报(自然科学版)》2025年第2期196-200,共5页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(22101243);信阳师范学院大学生科研基金项目(2022‑DXS‑089)。

摘　　要：以六甲基二硅氮烷(HMDS)为硅基化试剂,发展了一种无催化剂、无溶剂条件下硅醚的绿色合成新方法。该方法可以适用于一级苄醇、杂芳基甲醇、烯丙醇和脂肪醇,甚至位阻较大的二级醇以及三级醇,也可以进一步拓展到酚类化合物,在室温下反应即可以高达99%收率的硅醚化产物,具有反应条件简单、易于操作、副产物少、绿色环保等优点,展现出较好的实用价值。Using hexamethyldisilazane(HMDS)as the silylation reagent for the green synthesis of silyl ether in the absence of catalyst and solvent was developed.The method can be applied for a variety of primary benzyl alcohols,heteroaryl methanols,allylic alcohols,aliphatic alcohols and even the more sterically hindered secondary alcohols and tertiary alcohols,affording the target silyl ether products only at room temperature with a yield of up to 99%.Moreover,the method can be easily extend to phenols.This new method has the advantages of simple reaction conditions,easy operation,less by‑products and environmental protection,showing good practical value.

关 键 词：硅醚 醇和酚 无催化剂 无溶剂 

分 类 号：O626[理学—有机化学]