可见光条件下溶剂依赖的芳基砜合成  

Solvent‑dependent aryl sulfone synthesis under visible‑light conditions

作　　者：唐林 吕歌 刘载昆 张鲁方 吴太俊 王小钰 TANG Lin;LYU Ge;LIU Zaikun;ZHANG Lufang;WU Taijun;WANG Xiaoyu(College of Chemistry and Chemical Engineering,Xinyang Normal University,Xinyang 464000,China;Xinyang Tenth Senior Middle School,Xinyang 464000,China)

机构地区：[1]信阳师范大学化学化工学院,河南信阳464000 [2]信阳市第十高级中学,河南信阳464000

出　　处：《信阳师范大学学报(自然科学版)》2025年第2期207-212,共6页Journal of Xinyang Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(21602190);河南省高等学校重点科研项目(23A150022);河南省青年骨干教师项目(2020GGJS154);信阳师范大学大学生科研基金项目(2023‑DXS‑083)。

摘　　要：报道了一种可见光驱动溶剂依赖的芳基砜合成策略。该策略以三(2‑苯基吡啶)合铱(Ir(ppy)3)为光催化剂,芳基磺酰氯和硼酸为底物,碳酸钾为碱,1,2‑二氯乙烷为溶剂,水为添加剂,在室温下通过蓝光照射可以32%~93%收率得到各种取代的芳基砜。该方法还可应用于塞来昔布药物类似物的合成修饰。A novel visible‑light‑driven solvent‑dependent strategy for the synthesis of aryl sulfones was demonstrated.With Ir(ppy)3 as photocatalyst,aryl sulfonyl chlorides and boronic acids as substrates,potassium carbonate as base,1,2‑dichloroethane as solvent and water as additive,the proposed strategy could afford various aryl sulfones in 32%~93%yields at room temperature under blue light irradiation.In addition,the application of the strategy in preparation of celecoxib analogue was achieved.

关 键 词：可见光催化 溶剂效应 自由基 芳基砜 

分 类 号：O626[理学—有机化学]