Unveiling the molecular and cellular links between obstructive sleep apnea-hypopnea syndrome and vascular aging  

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作  者:Wei Liu Le Zhang Wenhui Liao Huiguo Liu Wukaiyang Liang Jinhua Yan Yi Huang Tao Jiang Qian Wang Cuntai Zhang 

机构地区:[1]Department of Geriatrics,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan,Hubei 430030,China [2]Key Laboratory of Vascular Aging,Ministry of Education,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan,Hubei 430030,China [3]Institute of Gerontology,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan,Hubei 430030,China [4]Department of Respiratory and Critical Care Medicine,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,No.1095 Jiefang Avenue,Wuhan,Hubei 430030,China

出  处:《Chinese Medical Journal》2025年第2期155-171,共17页中华医学杂志(英文版)

基  金:supported by the National Key Research and Development Program of China(No.2023YFC3605102);the Natural Science Foundation of Wuhan(No.2024040801020345);the Key Research and Development Program of Hubei Province(No.2022BCA001);the Hubei Provincial Natural Science Foundation(No.2023AFB685);the National Natural Science Foundation of China(No.82270104);Health Commission of Hubei Province Scientific Research Project(No.WJ2023Z010);the Postdoctor Project of Hubei Province(No.2024HBBHCXB025);Tongji Hospital Fund Cultivation Project(No.2024B10).

摘  要:Vascular aging(VA)is a common etiology of various chronic diseases and represents a major public health concern.Intermittent hypoxia(IH)associated with obstructive sleep apnea-hypopnea syndrome(OSAHS)is a primary pathological and physiological driver of OSAHS-induced systemic complications.A substantial proportion of OSAHS patients,estimated to be between 40%and 80%,have comorbidities such as hypertension,heart failure,coronary artery disease,pulmonary hypertension,atrial fibrillation,aneurysm,and stroke,all of which are closely associated with VA.This review examines the molecular and cellular features common to both OSAHS and VA,highlighting decreased melatonin secretion,impaired autophagy,increased apoptosis,increased inflammation and pyroptosis,increased oxidative stress,accelerated telomere shortening,accelerated stem cell depletion,metabolic disorders,imbalanced protein homeostasis,epigenetic alterations,and dysregulated neurohormonal signaling.The accumulation and combination of these features may underlie the pathophysiological link between OSAHS and VA,but the exact mechanisms by which OSAHS affects VA may require further investigation.Taken together,these findings suggest that OSAHS may serve as a novel risk factor for VA and related vascular disorders,and that targeting these features may offer therapeutic potential to mitigate the vascular risks associated with OSAHS.

关 键 词:Obstructive sleep apnea-hypopnea syndrome Vascular aging Intermittent hypoxia Molecular and cellular mechanisms 

分 类 号:R766[医药卫生—耳鼻咽喉科]

 

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