All Optic-Fiber Waveguide-Coupled SPR Sensor for CRP Sensing Based on Dielectric Layer and Poly-Dopamine  

作　　者：Jinying MA Shixin LI Xiangdong HUANG Junfeng JIANG Tianhua XU Tiegen LIU 

机构地区：[1]School of Electronic Engineering,Tianjin University of Technology and Education,Tianjin 300222,China [2]School of Electrical and Information Engineering,Tianjin University,Tianjin 300072,China [3]Institute of Optical Fiber Sensing,Tianjin University,Tianjin 300072,China [4]Key Laboratory of Opto-Electronics Information Technology,Ministry of Education,Tianjin 300072,China [5]School of Engineering,University of Warwick,Coventry CV47AL,UK

出　　处：《Photonic Sensors》2025年第2期98-109,共12页光子传感器(英文版)

基　　金：funded by the National Key Research and Development Program of China(Grant No.2022YFF0706003);National Natural Science Foundation of China(Grant No.62375202).

摘　　要：We developed an all optic-fiber waveguide-coupled surface plasmon resonance(SPR)sensor using zirconium disulfide(ZrS_(2))and poly-dopamine(PDA)as the dielectric layer and biological cross-linker,respectively.This sensor can be employed to monitor the entire process of the C-reactive protein(CRP)sensing,including antibody modification and antigen detection.The design and the optimization of the optical fiber waveguide-coupled SPR sensor were realized,based on the transfer matrix method and first-principles calculations.The sensor was fabricated and characterized according to the optimized parameters.The experimental setup was implemented to measure the entire process of antibody modification and antigen detection for CRP with the detection limit of 3.21 pmol·mL^(-1),and the specificity tests were also carried out.

关 键 词：Surface plasmon resonance(SPR) dielectric layer poly-dopamine(PDA) C-reactive protein(CRP) 

分 类 号：O436[机械工程—光学工程]