Micro/Nano Lasers for Biomolecular Sensing and Cellular Analysis  

作　　者：Xiaoqin WU Chunyan ZHU Yipei WANG Xudong FAN 

机构地区：[1]Key Laboratory of Optoelectronic Technology&Systems(Ministry of Education),College of OptoelectronicEngineering,Chongqing University,Chongqing 400044,China [2]Department of Biomedical Engineering,University of Michigan,Ann Arbor 48109,USA

出　　处：《Photonic Sensors》2025年第1期81-113,共33页光子传感器(英文版)

基　　金：supported by the National Natural Science Foundation of China(Nos.62005031 and 62005032);National Foreign Experts Program(No.DL2023165003L);Innovation Support Plan for Returned Overseas Scholars(No.cx2021058)to Xiaoqin WU and Yipei WANG,and the Richard A.Auhll Endowed Professorship to Xudong FAN.

摘　　要：Due to the stimulated emission amplification,lasers with excellent characteristics,including the high energy density,ultra-narrow spectral linewidth,and high directionality,are extremely favorable for sensing,detection,and imaging.Bringing these merits into the micro/nano scale,micro/nano lasers with miniaturized device sizes further enable outstanding spatial and temporal confinement,greatly boosting the light-matter interaction and bridging the size mismatch between light and biomolecules.Thanks to these advantages,micro/nano lasers have drawn widespread attention and opened new opportunities for a variety of biomedical and biochemical applications.In this paper,we review recent developments in biomolecular sensing and cellular analysis based on micro/nano lasers.We first describe the fundamental building blocks of micro/nano lasers,with discussions on gain material considerations,cavity structures,and pumping.We then review recent applications using micro/nano lasers as biosensors and bioprobes,including biomolecule(mainly proteins and DNAs)sensing,wavelength-multiplexed cell labeling/tracking/probing,and high-resolution cellular/tissue bioimaging.Finally,an outlook of the challenges and potential developments of micro/nano lasers for biological sensing and clinical applications is provided.

关 键 词：Micro/nano lasers CAVITY biomolecular sensing protein DNA cell analysis TISSUE 

分 类 号：O436[机械工程—光学工程] TN248[理学—光学]