基于网络药理学探讨香包中常见芳香类药物治疗疫病的作用机制  

Mechanism Explanation of Common Aromatic Drugs in Sachet for Preventing Epidemic Disease by Network Pharmacology

作　　者：井明博[1,2,3] 韩丽丽 姚炳旭 秦雪雪 王金成[1,2] 李东波 姜玉兰[1] JING Ming-bo;HAN Li-li;YAO Bing-xu;QIN Xue-xue;WANG Jin-cheng;LI Dong-bo;JIANG Yu-lan(College of Life Science and Technology,Longdong University,Qingyang 745000,Gansu;Provincial Key Laboratory of BiologicalResources Conservation and Utilization in Longdong,Qingyang 745000,Gansu;Institute of Medicinal Plants in Loess Plateau,Qingyang 745000,Gansu)

机构地区：[1]陇东学院生命科学与技术学院,甘肃庆阳745000 [2]甘肃省陇东生物资源保护利用与生态修复重点实验室,甘肃庆阳745000 [3]黄土高原药用植物研究所,甘肃庆阳745000

出　　处：《陇东学院学报》2025年第2期96-102,共7页Journal of Longdong University

基　　金：甘肃省自然科学基金项目“陇东黄土高原地区土壤因子对原油降解合成菌落结构与功能的影响机制研究”(21JR1RM333);陇东学院大学生创新创业训练计划项目“基于网络药理学设计上工驱邪安康香丸”(20221123)。

摘　　要：为了探讨香包中芳香类药物治疗疫病的作用机制,以常用芳香类药物丁香、大黄、金银花、白芷、陈皮、桑叶为研究对象,采用网络药理学的方法筛选活性成分及其作用靶点、疫病的潜在治疗靶点、构建药物对疫病的“药物——成分——交集靶点基因”网络及蛋白相互作用(PPI)网络,并对潜在作用靶点进行GO和KEGG富集分析其作用通路分析。结果显示,香包中芳香类药物可能通过红厚壳内酯Inophyllum E、白当归脑Byakangelicol等11种活性成分,作用于蛋白激酶AKT1、肿瘤坏死因子TNF、甘油醛-3-磷酸脱氢酶GAPDH等5个核心作用靶点蛋白,通过参与脂质体与动脉粥样硬化途径、糖基化产物及其受体途径、癌症途径、麻疹病毒感染途径、人疱疹病毒感染途径、乙型肝炎途径等多条信号通路共同发挥作用。To explore the mechanism of aromatic drugs in the treatment of infectious diseases,Syringa oblata Lindl,Rheum palmatum L,Lonicera japonica Thunb,Angelica dahurica Benth,Pericarpium citri Reticulatae,and Mori Folium were used as the research objects,and the network pharmacological methods were used to selected the active components,their targets and potential therapeutic targets of infectious diseases.The‘drug-component-overlapping gene’network and the protein-protein interaction(PPI)network of the aromatic drugs were construct,and the GO and KEGG enrichment analyze were used to clarify the potential targets.The results showed that the aromatic compounds in the sachet could be separated by 11 active components,such as Inophyllum E and Byakangelicol,and they may act on five core proteins targets,namely AKT1,TNF,GAPDH,VEGFA,EGFR.They are involved in signaling pathways,such as liposome and arteriosclerosis pathway,AGE-RAGE signaling pathway,cancer pathway,measles pathway,human herpesvirus infection pathway,hepatitis B pathway,and so on.

关 键 词：芳香类药物 疫病 网络药理学 

分 类 号：R932[医药卫生—生药学]