蝉蜕僵蚕配四君子汤联合孟鲁司特钠治疗慢性咳嗽疗效观察  

Observation on the Therapeutic Effect of Chantui Jiangcan and Sijunzi Decoction Combinedwith Montelukast Sodium in the Treatment of Chronic Cough

作　　者：谢雅婷 邓水露 XIE Yating;DENG Shuilu(Department of Traditional Chinese Medicine(Department of Preventive Medicine),Xingtang Hospital of Suzhou Industrial Park,Suzhou 215009,China;Department of Emergency and Critical Care Medicine,The Affiliated Suzhou Hospitalof Nanjing Medical University(Suzhou Municipal Hospital),Suzhou 215002,China)

机构地区：[1]苏州工业园区星塘医院中医科(治未病科),江苏苏州215009 [2]南京医科大学附属苏州医院(苏州市立医院)急危重症医学部,江苏苏州215002

出　　处：《中西医结合研究》2025年第2期73-76,共4页Research of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察蝉蜕、僵蚕配四君子汤联合孟鲁司特钠治疗慢性咳嗽的临床效果。方法选取2023年9月—2024年6月本院收治的慢性咳嗽患者120例,随机分为2组,每组60例。对照组予以孟鲁司特钠治疗,试验组在对照组用药基础上予以蝉蜕、僵蚕配四君子汤治疗。比较2组患者治疗前后咳嗽视觉模拟评分法(visual analogue scale,VAS)、简易咳嗽程度评分表(cough evaluation test,CET)、莱彻斯特咳嗽问卷(Leicester cough questionnaire,LCQ)评分及诱导痰液白介素(interleukin,IL)-4、肿瘤坏死因子(tumor necrosis factor,TNF)-α、IL-6水平,比较2组患者临床疗效及不良反应发生情况。结果治疗2周后,试验组总有效率显著高于对照组(P<0.05);试验组VAS、CET评分及诱导痰液IL-4、TNF-α、IL-6水平显著低于对照组(P<0.05),LCQ评分显著高于对照组(P<0.05)。治疗过程中,2组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论蝉蜕、僵蚕配四君子汤联合孟鲁司特钠治疗慢性咳嗽能改善患者症状,抑制气道炎症,提高临床疗效,且安全性良好。Objective To observe the clinical effect of Chantui Jiangcan and Sijunzi decoction combined with montelukast sodium in the treatment of chronic cough.Methods One hundred and twenty patients with chronic cough admitted to our hospital from September 2023 to June 2024 were randomly divided into two groups,with 60 cases in each group.The control group was treated with montelukast sodium,while the experimental group was treated with Chantui Jiangcan and Sijunzi decoction on the basis of the control group's medication.Visual analogue scale(VAS),cough evaluation test(CET),Leicester cough questionnaire(LCQ)scores,and induced sputum interleukin(IL)-4,tumor necrosis factor(TNF)-α,and IL-6 levels between two groups of patients were compared before and after treatment.The clinical efficacy and incidence of adverse reactions between two groups of patients were compared.Results After 2 weeks of treatment,the total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).VAS,CET scores and induced sputum IL-4,TNF-α,IL-6 levels in the experimental group were significantly lower than those in the control group(P<0.05),LCQ score was significantly higher than that in the control group(P<0.05).During the treatment,there was no statistical significance in the incidence of adverse reactions between two groups of patients(P>0.05).Conclusion Chantui Jiangcan and Sijunzi decoction combined with montelukast sodium could improve the symptoms of patients with chronic cough,inhibit airway inflammation,improve clinical efficacy,and has good safety.

关 键 词：慢性咳嗽 孟鲁司特钠 四君子汤 蝉蜕 僵蚕 

分 类 号：R256.11[医药卫生—中医内科学]