葡萄糖氧化酶在动物生产中的应用  

Application of glucose oxidase in animal production

作　　者：王玥 赵紫茵 姚子豪 张飞燕[3] 高庆华 唐兆宏 WANG Yue;ZHAO Ziyin;YAO Zihao;ZHANG Feiyan;GAO Qinghua;TANG Zhaohong

机构地区：[1]河北省微生物研究所有限公司,河北保定071051 [2]河北农业大学动物科技学院,河北保定071051 [3]河北省科学院生物研究所,河北石家庄050081 [4]保定鲜尔康生物工程有限责任公司,河北保定071051

出　　处：《饲料研究》2025年第5期163-168,共6页Feed Research

基　　金：河北省科学院高层次人才培养与资助项目(项目编号:2024G14)。

摘　　要：葡萄糖氧化酶(GOD)属于葡萄糖-甲醇-胆碱氧化还原酶(GMC)家族,能够利用氧气和β-D-葡萄糖氧化为葡萄糖酸(GA),同时生成过氧化氢(H_(2)O_(2)),已被广泛应用于畜牧业、生物医药和食品工业等多个领域。在动物生产中,GOD作为一种新型饲料添加剂,不仅具有促生长、抗生素替代潜力,而且在增强机体抗氧化能力、维持肠道菌群稳态、改善肠道健康、提高生产性能、增强免疫力等方面发挥重要作用。文章综述了GOD的结构、催化机理和理化性质及其对动物生长调节作用的主要机制,以及近年来GOD在家禽、猪和反刍动物生产中的应用现状,并对其开发与利用进行了展望,以推动GOD在畜牧业中的高效利用。Glucose oxidase(GOD)belongs to the glucose-methanol-choline oxidoreductase(GMC)family and is capable of utilizing oxygen to oxidizeβ-D-glucose into gluconic acid(GA),while simultaneously generating hydrogen peroxide(H_(2)O_(2)).It has been widely applied in various fields such as animal husbandry,biomedicine,and the food industry.In animal production,GOD serves as a novel feed additive,not only exhibiting growth-promoting and antibioticalternative potential,but also playing a significant role in enhancing the body's antioxidant capacity,maintaining intestinal microbiota homeostasis,improving gut health,boosting production performance,and strengthening immune function.This article reviews the main mechanisms of GOD's regulatory effects on animal growth,based on its structure,catalytic mechanism,and physicochemical properties.It also summarizes the recent applications of GOD in poultry,pig,and ruminants,and provides an outlook on its development and utilization,aiming to promote efficient use of GOD in the animal husbandry.

关 键 词：葡萄糖氧化酶 作用机制 动物生产 

分 类 号：S816.7[农业科学—饲料科学]