Co-Benefits of Antimicrobial Resistance Mitigation from China’s PM_(2.5)Air Pollution Reduction Between 2014-2020  

作　　者：Zhenchao Zhou Zejun Lin Xinyi Shuai Xiaoliang Ba Chioma Achi Mark AHolmes Tong Xu Yingru Lu Yonghong Xiao Jianming Xu Baojing Gu Hong Chen 

机构地区：[1]College of Environmental and Resource Sciences,Zhejiang University,Hangzhou 310058,China [2]Department of Veterinary Medicine,University of Cambridge,Cambridge CB30ES,UK [3]Ineos Oxford Institute of Antimicrobial Research,Department of Biology,University of Oxford,Oxford OX13RE,UK [4]Centre for Environment,Energy and Natural Resource Governance,Department of Land Economy,University of Cambridge,Cambridge CB30ES,UK [5]UK of Intensive Care Unit,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou 325000,China [6]State Key Laboratory for Diagnosis and Treatment of Infectious Disease,The First Affiliated Hospital,Zhejiang University,Hangzhou 310003,China [7]International Cooperation Base of Environmental Pollution and Ecological Health,Science and Technology Agency of Zhejiang,Zhejiang University,Hangzhou 310058,China

出　　处：《Engineering》2025年第2期243-251,共9页工程(英文)

基　　金：funded by the National Natural Science Foun-dation of China(22406168,W2411031,and 52270201);the China Postdoctoral Science Foundation(2023M733061);the Zhejiang University Global Partnership Fund(100000-11320/198).

摘　　要：The One Health concept acknowledges the importance of multiple dimensions in controlling antimicrobial resistance(AMR).However,our understanding of how anthropological,socioeconomic,and environmental factors drive AMR at a national level remains limited.To explore associations between potential contributing factors and AMR,this study analyzed an extensive database comprising 13 major antibioticresistant bacteria and over 30 predictors(e.g.,air pollution,antibiotic usage,economy,husbandry,public services,health services,education,diet,climate,and population)from 2014 to 2020 across China.The multivariate analysis results indicate that fine particulate matter with a diameter of 2.5 μm or less(PM_(2.5))is associated with AMR,accounting for 12%of the variation,followed by residents’income(10.3%)and antibiotic usage density(5.1%).A reduction in PM_(2.5)of 1 μg·m^(-3)is linked to a 0.17%decrease in aggregate antibiotic resistance(p<0.001,R^(2)=0.74).Under different scenarios of China’s PM_(2.5)airquality projections,we further estimated the premature death toll and economic burden derived from PM_(2.5)-related antibiotic resistance in China until 2060.PM_(2.5)-derived AMR is estimated to cause approximately 27000(95%confidence interval(CI):646848830)premature deaths and about 0.51(95%CI;0.12-0.92)million years of life lost annually in China,equivalent to an annual welfare loss of 8.4(95%CI;2.0-15.0)billion USD.Implementing the“Ambitious Pollution 1.5℃ Goals”scenario to reduce PM_(2.5)concentrations could prevent roughly 14000(95%CI;3324-26320)premature deaths—with a potential monetary value of 9.8(95%CI;2.2-17.6)billion USD—from AMR by 2060.These results suggest that reducing air pollution may offer co-benefits in the health and economic sectors by mitigating AMR.

关 键 词：Antimicrobial resistance Air pollution Antibiotic usage Multivariable analysis Premature deaths NATIONWIDE 

分 类 号：X51[环境科学与工程—环境工程]