基于数据挖掘的中药方剂治疗血管性痴呆用药规律研究  

Medication Patterns of Traditional Chinese Medicine Prescriptions for Vascular Dementia Based on Data Mining

作　　者：曾参[1] 付胜楠 蔡婕 钱江[2] 倪穗琴[1] ZENG Shen;FU Shengnan;CAI Jie;QIAN Jiang;NI Suiqin(Department of Pharmacy,Guangzhou First People's Hospital,Guangzhou 510000,China;Laboratory Animal Center of Sun Yat-sen University,Guangzhou 510000,China)

机构地区：[1]广州市第一人民医院药学部,广东广州510000 [2]中山大学实验动物中心,广东广州510000

出　　处：《基层中医药》2025年第3期92-98,共7页Basic Traditional Chinese Medicine

基　　金：广州市卫生健康科技项目(广州市中医药和中西医结合科技项目)(2022A010010)。

摘　　要：目的 检索公开数据库中治疗血管性痴呆(VaD)中药方剂,分析其用药规律。方法通过检索中国知网、维普、万方及PubMed数据库中从建库之时起至2020年治疗VaD的文献,建立中药方剂数据库,根据证候进行分类,运用数据挖掘方法对各证型中药的使用频次、药物功效、性味归经等进行统计分析,并分析其用药差异。结果 纳入分析方剂305组,证型分类11种,常用中药为石菖蒲、川芎、远志、丹参、黄芪、何首乌、茯苓、当归、山茱萸、水蛭等,而肝阳上亢型最常用的中药是黄芩。根据关联分析得出常用药对21个,药组19个。结论 在中药方剂方面,除肝阳上亢型用药特殊,其他各证型常用中药略有差异,其核心药物多为石菖蒲和川芎,以活血、开窍为主要治疗原则,辅以清燥、补气、固精、润下等进行配伍。Objective To analyze the medication patterns of traditional Chinese medicine(TCM)for vascular dementia(VD)after screening public databases.Methods By retrieving literature on the treatment of VD from CNKI,VIP database,Wanfang database,and PubMed database from the establishment time of the above databases to 2020,this paper established a database of TCM prescriptions and categorizes them according to syndromes.Then,it statistically analyzed the frequency of usage,medicinal efficacy,properties,flavors,and channel tropism of the prescriptions, and investigated the differences in medication patterns. Results A total of 305 TCM prescriptionstargeted for 11 types of syndromes were obtained. Among them, the commonly used traditionalChinese medicines include Acori Tatarinowii Rhizoma, Chuanxiong Rhizoma, Polygalae Radix, SalviaeMiltiorrhizae Radix et Rhizoma, Astragali Radix, Polygoni Multiflori Radix, Poria, Angelicae SinensisRadix, Corni Fructus, and Hirudo, and Scutellariae Radix is the most commonly used medicine forthe hyperactivity of liver yang pattern. Based on association analysis, 21 couplet medicines and 19medicine groups were identified. Conclusion Except for the hyperactivity of the liver yang patternwhich requires unique medication patterns, the commonly used medicines for other syndromes onlyshow slight variations, with Acori Tatarinowii Rhizoma and Chuanxiong Rhizoma as the core ones. Theprimary treatment principles focus on activating blood circulation and resuscitation, complementedby medicines that possess the functions of clearing dryness, tonifying qi, consolidating essence, andmoistening and purgation.

关 键 词：血管性痴呆 中药方剂 数据挖掘 

分 类 号：R277.7[医药卫生—中医学]