基于网络药理学分析四逆加人参汤治疗心肌梗死合并心力衰竭的作用机制  

Analyze the mechanism of action of Sini Jia Renshen decoction in the treatment of myocardial infarction complicated with heart failure based on network pharmacology

作　　者：陈旭峰[1] 武富平 CHEN Xufeng;WU Fuping(Department of Cardiovascular,Tongde Hospital of Zhejiang Province,Hangzhou 310012,Zhejiang,China;College of Integrated Traditional Chinese and Western Medicine Clinical Medicine,Zhejiang Chinese Medical University,Hangzhou 310012,Zhejiang,China)

机构地区：[1]浙江省立同德医院心血管科,浙江杭州310012 [2]浙江中医药大学中西医结合临床医学院,浙江杭州310012

出　　处：《中国现代医生》2025年第10期42-46,共5页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2022ZA041)。

摘　　要：目的基于网络药理学分析四逆加人参汤治疗心肌梗死合并心力衰竭的作用机制。方法运用中药系统药理学数据库和分析平台检索四逆加人参汤的活性成分;利用String和UniProt数据库获取四逆加人参汤的作用靶点,通过GeneCards、OMIM等数据库检索心肌梗死合并心力衰竭的相关靶点,获取药物活性成分作用靶点与疾病相关靶点交集,并对交集靶点进行基因本体论和京都基因与基因组数据库富集分析。结果获得四逆加人参汤的活性成分112个,药物活性成分作用靶点233个,心肌梗死合并心力衰竭的相关靶点4980个,药物与疾病的交集靶点共188个。槲皮素、β-谷甾醇、异鼠李素、柚皮素是四逆加人参汤治疗心肌梗死合并心力衰竭的核心活性成分。通路富集分析结果显示主要涉及脂质与动脉粥样硬化、晚期糖基化终末产物(advanced glycation end product,AGE)/AGE受体、剪切应力激活的血管内皮、白细胞介素-17等信号通路。结论四逆加人参汤治疗心肌梗死合并心力衰竭具有多成分、多靶点、多通路的特点,其可能通过脂质与动脉粥样硬化等通路对疾病发挥治疗作用。Objective To analyze the mechanism of action of Sini Jia Renshen decoction in the treatment of myocardial infarction complicated with heart failure based on network pharmacology.Methods Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform was used to search the active ingredients of Sini Jia Renshen decoction.The target of Sini Jia Renshen decoction was obtained by using String and UniProt database.Targets related to myocardial infarction complicated with heart failure were searched through GeneCards database,OMIM database,etc.Obtain the intersection of the target of the active ingredient and the disease-related target.Gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis of intersection targets were carried out.Results There were 112 active ingredients of Sini Jia Renshen decoction,233 active ingredients and 4980 associated targets of myocardial infarction complicated with heart failure.The intersection targets of drugs and diseases were 188.Quercetin,β-sitosterol,isorhamnetin and naringenin were the core active ingredients of Sini Jia Renshen decoction treatment of myocardial infarction complicated with heart failure.The pathway enrichment analysis showed that it was mainly involved in lipid and atherosclerosis,advanced glycation end product(AGE)/AGE receptor,vascular endothelium activated by shear stress,interleukin-17 and other signaling pathways.Conclusion The treatment of myocardial infarction complicated with heart failure by Sini Jia Renshen decoction has the characteristics of multi-components,multi-targets and multi-pathways.It may play a role in myocardial infarction complicated with heart failure through lipid and atherosclerosis pathways and so on.

关 键 词：心肌梗死 心力衰竭 四逆加人参汤 网络药理学 

分 类 号：R256.21[医药卫生—中医内科学]