补肾养血调经汤对异常子宫出血患者的影响  

Effect of Bushen Yangxue Tiaojing Tang for patients with abnormal uterine bleeding

作　　者：何锦妮 尚国涛 任利 李翡[3] He Jinni;Shang Guotao;Ren Li;Li Fei(Department of Gynecology,Yangling Demonstration Zone Hospital,Xianyang 712100,China;Department of Traditional Chinese Medicine,Yangling Demonstration Zone Hospital,Xianyang 712100,China;Second Department of Gynecology,Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China)

机构地区：[1]杨凌示范区医院妇科,咸阳712100 [2]杨凌示范区医院中医科,咸阳712100 [3]陕西中医药大学妇二科,咸阳712000

出　　处：《国际医药卫生导报》2025年第8期1316-1320,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(20200F-052)。

摘　　要：目的探讨补肾养血调经汤对异常子宫出血患者子宫内膜厚度、凝血功能及血清激素水平的影响。方法采用前瞻性研究,选取2021年1月至2024年1月在杨凌示范区医院治疗的异常子宫出血患者100例作为研究对象,按照随机数字表法分为对照组(50例)和观察组(50例)。对照组年龄(33.13±7.29)岁,病程(3.79±0.65)年,予以常规西药治疗;观察组年龄(32.89±7.51)岁,病程(3.83±0.61)年,在对照组基础上联合补肾养血调经汤治疗。对比两组临床疗效、中医症候积分、临床相关指标、凝血功能指标[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)]、性激素指标[卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)]及不良反应发生情况。统计学方法采用t检验、χ^(2)检验、秩和检验。结果观察组总有效率为98.0%(49/50),高于对照组的80.0%(40/50),差异有统计学意义(P<0.05)。治疗后,观察组腰膝酸软[(1.12±0.23)分]、头晕目眩[(1.23±0.32)分]、性欲减退[(1.16±0.27)分]、口干舌燥[(1.05±0.16)分]、舌红少苔[(1.13±0.15)分]、脉沉细评分[(1.03±0.12)分]及FIB[(2.19±0.13)g/L]、FSH[(14.27±1.45)mIU/L]、LH[(6.15±1.12)mIU/L]、E2指标[(179.23±15.35)ng/L]均低于对照组[(1.65±0.31)分、(1.78±0.36)分、(1.64±0.35)分、(1.46±0.19)分、(1.49±0.23)分、(1.54±0.35)分、(2.61±0.12)g/L、(22.29±2.19)mIU/L、(8.28±1.65)mIU/L、(254.68±20.35)ng/L];月经周期[(31.21±3.15)d]、APTT[(28.65±3.12)s]、PT[(14.23±1.35)s]均短于对照组[(44.26±4.19)d、(30.35±3.26)s、(15.68±2.39)s];月经量少于对照组[(46.29±10.42)ml比(65.15±13.82)ml];子宫内膜厚度小于对照组[(5.25±0.16)mm比(7.05±0.21)mm];差异均有统计学意义(均P<0.05)。两组不良反应发生率比较,差异无统计学意义(χ^(2)=0.271,P=0.603)。结论补肾养血调经汤治疗异常子宫出血患者疗效较好,可改善患者体征、症状、凝血功能和性激素水平,并促进月经量Objective To investigate the effect of Bushen Yangxue Tiaojing Tang on endometrial thickness,coagulation function,and serum hormone levels in patients with abnormal uterine bleeding.Methods This was a prospective study.One hundred patients with abnormal uterine bleeding treated at Yangling Demonstration Zone Hospital from January 2021 to January 2024 were selected as the study objects,and were divided into a control group and an observation group by the random number table method,with 50 cases in each group.There control group were(33.13±7.29)years old;their disease course was(3.79±0.65)years.The observation group were(32.89±7.51)years old;their disease course was(3.83±0.61)years.The control group were conventionally treated with western medicine;in addition,the observation group took Bushen Yangxue Tiaojing Tang.The clinical efficacies,scores of traditional Chinese medicine syndromes,clinically relevant indicators,coagulation function indicators[activated partial thromboplastin time(APTT),prothrombin time(PT),and fibrinogen(FIB)],sex hormone indicators[follicle stimulating hormone(FSH),luteinizing hormone(LH),and estradiol(E2)],and incidence rates of adverse reactions were compared between the two groups.The statistical methods included t test,χ^(2) test,and rank sum test.Results The total efficacy in the observation group was higher than that in the control group[98.0%(49/50)vs.80.0%(40/50)],with a statistical difference(P<0.05).The scores of soreness in the waist and knees,dizziness,hyposexuality,dry mouth and tongue,red tongue with little coating,and deep and thin pulse and the levels of FIB,FSH,LH,and E2 in the observation group were lower than those in the control group[1.12±0.23 vs.1.65±0.31,1.23±0.32 vs.1.78±0.36,1.16±0.27 vs.1.64±0.35,1.05±0.16 vs.1.46±0.19,1.13±0.15 vs.1.49±0.23,1.03±0.12 vs.1.54±0.35,(2.19±0.13)g/L vs.(2.61±0.12)g/L,(14.27±1.45)mIU/L vs.(22.29±2.19)mIU/L,(6.15±1.12)mIU/L vs.(8.28±1.65)mIU/L,(179.23±15.35)ng/L vs.(254.68±20.35)ng/L];the menstruation period,APTT,

关 键 词：补肾养血调经汤 异常子宫出血 子宫内膜厚度 凝血功能 性激素 

分 类 号：R271.9[医药卫生—中西医结合]