吸入用布地奈德混悬液联合福多司坦片对支气管哮喘急性发作患者气道高反应及黏液高分泌的影响  

Effects of Inhaled Budesonide Suspension Combined with Fodosteine Tablets on Airway Hyperresponsiveness and Mucus Hypersecretion in Patients with Acute Attack of Bronchial Asthma

作　　者：李丹 孙思 李甜甜 刘霞[1] 宋琳琳 LI Dan;SUN Si;LI Tiantian;LIU Xia;SONG Linlin(Department of Respiratory and Critical Care Medicine,Xuzhou Central Hospital,Xuzhou 221000,China)

机构地区：[1]江苏省徐州市中心医院呼吸与危重症医学科,江苏徐州221000

出　　处：《中国伤残医学》2025年第4期75-79,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探讨吸入布地奈德混悬液与福多司坦片联合治疗支气管哮喘急性发作患者的效果,并分析其对患者黏液高分泌和气道高反应的影响。方法:选择2020年6月-2023年6月徐州市中心医院收治的80例支气管哮喘急性发作患者为研究对象,随机将其分为对照组和研究组,各40例。两组均给予常规对症治疗,在此基础上对照组给予布地奈德吸入治疗,研究组在对照组基础上联合福多司坦片治疗。两组均治疗14 d。比较两组临床症状消失时间、痰液量、痰液黏度、黏液高分泌指标、肺功能指标、炎性指标、免疫功能指标。结果:治疗后,两组第1秒用力呼气容积、用力肺活量均较治疗前增大,且研究组均大于对照组,两组呼气流量峰值均较治疗前增快,且研究组快于对照组,两组免疫球蛋白(Ig)M、IgA、IgG均较治疗前升高,且研究组相较于对照组高,差异均有统计学意义(P<0.05)。治疗后,两组每日痰液量、痰液干/湿重比、痰液黏度、中性粒细胞弹性蛋白酶、黏蛋白5ac含量均较治疗前降低,且研究组均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组C反应蛋白、白细胞介素-6、肿瘤坏死因子-α及降钙素原水平均较治疗前降低,且研究组均低于对照组,差异均有统计学意义(P<0.05)。研究组发热、呼吸困难、咳嗽及肺部湿啰音的消失时间均短于对照组,差异均有统计学意义(P<0.05)。结论:吸入用布地奈德混悬液与福多司坦片联合治疗支气管哮喘急性发作患者能够显著缓解其临床症状,有效降低黏液高分泌状态,降低痰液量,减轻痰液黏度及炎症反应,提高免疫功能及肺功能,具有一定的应用价值。Objective:To investigate the effect of Budesonide Suspension combined with Fodosteine Tablets in the treatment of patients with acute attack of bronchial asthma,and to analyze its effect on hypersecretion of mucus and airway hyperresponse in patients.Methods:A total of 80 patients with acute attack of bronchial asthma admitted to Xuzhou Central Hospital from June 2020 to June 2023 were selected as the study objects and randomly divided into a control group and a study group,with 40 cases in each group.Both groups were given conventional symptomatic treatment,the control group was given Budesonide Suspensio therapy,and the study group was treated with Fodosteine Tablets based on the control group.Both groups were treated for 14 days.The duration of clinical symptoms,sputum volume,sputum viscosity,mucus hypersecretion,lung function,inflammation and immune function were compared between the two groups.Results:After treatment,the forced expiratory volume and forced vital capacity in the first second of both groups were increased compared with before treatment,and the study group was larger than the control group,peak expiratory flow in both groups were increased faster than before treatment,and the study group was faster than the control group,immunoglobulin(Ig)M,IgA and IgG in both groups were higher than before treatment,and the study group was higher than the control group,the differences were statistically significant(P<0.05).After treatment,the daily sputum volume,dry/wet weight ratio of sputum,sputum viscosity,neutrophil elastase and mucin 5ac contents in both groups were lower than before treatment,and the study group were lower than the control group,with statistical significance(P<0.05).After treatment,C-reactive protein,interleukin-6,tumor necrosis factor-αand procalcitoninr in two groups were lower than before treatment,and the study group was lower than the control group,the differences were statistically significant(P<0.05).The time to resolve fever,dyspnea,cough,and lung rales in the study group was sh

关 键 词：支气管哮喘 急性发作 吸入用布地奈德混悬液 福多司坦片 气道高反应 黏液高分泌 并发症 

分 类 号：R562.2[医药卫生—呼吸系统]