酪酸梭菌二联活菌散联合蒙脱石散对急性感染性腹泻伴轻度胃肠功能障碍患儿的临床治疗效果探究  

Clinical Efficacy of Combined Clostridium Butyricum and Bifidobacterium Powders,Live Combined with Montmorillonite Powder in the Treatment of Children with Acute Infectious Diarrhea Accompanied by Mild Gastrointestinal Dysfunction

作　　者：吴琳 WU Lin(Department of Pediatrics,Zibo Zhangdian District Maternal and Child Health Hospital,Zibo 255000,China)

机构地区：[1]山东省淄博市张店区妇幼保健院儿科,山东淄博255000

出　　处：《中国伤残医学》2025年第4期80-84,共5页Chinese Journal of Trauma and Disability Medicine

摘　　要：目的:探究酪酸梭菌二联活菌散联合蒙脱石散对急性感染性腹泻伴轻度胃肠功能障碍患儿的临床诊疗效果。方法:回顾性分析2020年1月-2024年8月张店区妇幼保健院收治的62例急性感染性腹泻伴轻度胃肠功能障碍患儿的临床资料,按照治疗方法的不同将其分为对照组和研究组,各31例。对照组采用蒙脱石散治疗,研究组在对照组基础上口服酪酸梭菌二联活菌散进行治疗。对比两组治疗效果、临床指标、大便性状、胃肠功能障碍情况及不良反应发生情况。结果:研究组治疗总有效率为100%,高于对照组的77.42%,差异有统计学意义(P<0.05)。研究组的大便形状改变时间、腹泻持续时间、肠鸣音恢复正常时间及大便镜检红细胞消失时间均短于对照组,差异均有统计学意义(P<0.05)。治疗1、3 d后,研究组的Bristol大便分类法评分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,研究组的急性胃肠损伤分级评分低于对照组,差异有统计学意义(P<0.05)。研究组不良反应发生率6.45%低于对照组的12.90%,但两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论:酪酸梭菌二联活菌散联合蒙脱石散对急性感染性腹泻伴轻度胃肠功能障碍患儿治疗的效果良好,有助于尽早改善腹泻症状,能够使大便性状更快恢复正常状态,具有一定安全性。Objective:To investigate clinical efficacy of Combined Clostridium Butyricum and Bifidobacterium Powders,Live combined with Montmorillonite Powder in the treatment of children with acute infectious diarrhea accompanied by mild gastrointestinal dysfunction.Methods:The clinical data of 62 children with acute infectious diarrhea accompanied by mild gastrointestinal dysfunction admitted to Zibo Zhangdian District Maternal and Child Health Hospital from January 2020 to August 2024 were retrospectively analyzed,according to the different treatment methods,they were divided into into a control group and a study group,with 31 cases in each group.The control group was treated with Montmorillonite Powder,while the study group was treated with Combined Clostridium Butyricum and Bifidobacterium Powders,Live on the basis of the control group.Compared the treatment effects,gastrointestinal hormones,stool property,incidence of gastrointestinal dysfunction and adverse reactions between two groups.Results:The total effective rate of treatment in the study group was 100%,which was higher than 77.42% in the control group,the difference was statistically significant(P<0.05).The change of stool shape time,the duration of diarrhea time,bowel sounds to return to normal time,and red blood cells to disappear on stool microscopy time in the control group were shorter than those in the control group,the differences were statistically significant(P<0.05).After 1 and 3 days of treatment,the Bristol Stool Classification scores in the study group were lower than those in the control group,the differences were statistically significant(P<0.05).After treatment,the grading score of Acute Gastrointestinal Injury in the study group was lower than that in the control group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the study group was 6.45% lower than 12.90% in the control group,but there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The c

关 键 词：感染性腹泻 胃肠功能障碍 酪酸梭菌二联活菌散 蒙脱石散 大便性状 

分 类 号：R725[医药卫生—儿科]