血清钙结合蛋白S100A9与特发性肺纤维化患者肺功能的相关性研究  

The correlation between serum calcium binding protein S100A9 and pulmonary function in patients with idiopathic pulmonary fibrosis

作　　者：张铁[1] 郑静 王国镇[1] 曹永彤[1] Zhang Tie;Zheng Jing;Wang Guozhen;Cao Yongtong(Department of Clinical Laboratory,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院检验科,北京100029

出　　处：《中华检验医学杂志》2025年第3期390-395,共6页Chinese Journal of Laboratory Medicine

基　　金：北京市临床重点专科(2020)。

摘　　要：目的探讨血清钙结合蛋白S100A9水平与特发性肺纤维化(IPF)患者肺功能的相关性。方法回顾性病例对照研究。选择2023年1月4日至2024年1月30日就诊于我院呼吸科并确诊为IPF的患者40例作为IPF组,其中男29例,女11例;年龄(65.3±8.4)岁,同时选择50例中日友好医院体检中心的健康体检者作为健康对照组,其中男38例,女12例;年龄(64.1±6.3)岁,检测血清S100A9水平以及肺功能。采用SPSS 19.0统计软件对数据进行统计学分析。采用参数检验(独立样本t检验)比较两组间血清S100A9水平以及肺功能差异,计数资料以例表示,采用χ2检验进行比较。采用Pearson相关性分析评价S100A9与肺功能的相关性,采用多因素Logistic回归分析IPF的危险因素,以受试者工作(ROC)曲线分析钙卫蛋白S100A9预测IPF的价值。结果IPF组血清S100A9水平高于健康对照组[(132.47±21.46)pg/ml,(44.75±8.84)pg/ml,t=3.544,P<0.05],第一秒用力呼气容积FEV1(1.38±0.19)L、用力肺活量FVC(2.38±0.59)L、第一秒用力呼气容积与用力肺活量的比值FEV1/FVC(57.98±6.13)、最大自主通气MVV(57.48±7.66)L/min均低于对照组[(3.24±0.65)L,(3.65±0.67)L,(88.77±7.97),(86.34±7.23)L/min,t=3.486;3.393;2.771;3.462,P<0.05]。S100A9与FEV1、FVC、FEV1/FVC、MVV、均呈负相关(r=-0.537;-0.458;-0.489;-0.511,P<0.05)。与肺泡灌洗液S100A9及高分辨率CT纤维化评分呈正相关(r=0.632,r=0.517;P<0.05)。S100A9预测IPF的曲线下面积为0.691。结论IPF患者钙结合蛋白S100A9水平增高,且与肺通气功能下降以及IPF发生密切相关,可以成为评估肺纤维化的标志物。Objective To investigate the correlation between serum calcium binding protein S100A9 levels and lung function in patients with idiopathic pulmonary fibrosis(IPF).Method A retrospective case-control study was conducted.Forty patients diagnosed with IPF in respiratory department from January 4,2023,to January 30,2024 were selected as the IPF group,with a mean age of(65.3±8.4)years old,including 29 males and 11 females.while 50 healthy volunteers receiving health examinations in our physical examination center were enrolled in this study,including 38 males and 12 females,with a mean age of(64.1±6.3)years.The levels of biochemical parameters were assayed with biochemical analyzer.S100A9 levels were determined by Enzyme linked immunosorbent assay.The lung function test results of all participants were recorded.SPSS 19.0 statistical software was used to compare the differences of biomarkers levels between the two groups,Using parameter testing(independent sample t-test)to compare the differences in serum S100A9 levels and lung function between the two groups,the enumeration data were treated with the chi-square test.Pearson correlation analysis was used to evaluate the correlation between S100A9 and lung function,the influencing factors of IPF were analyzed by using multivariate logistic regression model,and receiver operating characteristic(ROC)curve analysis was used to assess the value of Calprotectin S100A9 in predicting IPF.Results The serum S100A9 levels in the IPF group were significantly higher than those in the healthy control group[(132.47±21.46)pg/ml,(44.75±8.84)pg/ml,t=3.544,P<0.05],forced expiratory volume in one second(FEV1,1.38±0.19)L,forced vital capacity(FVC,2.38±0.59)L,FEV1/FVC(57.98±6.13),the maximum spontaneous ventilation(MVV,57.48±7.66)L/min was lower than that of the control group[(3.24±0.65)L,(3.65±0.67)L,(88.77±7.97),(86.34±7.23)L/min,t=3.486,3.393,2.771,3.462,P<0.05].Serum S100A9 was negatively correlated with FEV1,FVC,FEV1/FVC,and MVV(r=-0.537,-0.458,-0.489,-0.511,P<0.05),S100A9

关 键 词：钙结合蛋白 特发性肺纤维化 肺功能 

分 类 号：R563[医药卫生—呼吸系统]