卡晏环孢子虫感染肾移植患者导致慢性腹泻1例  

A case of kidney transplant patient with chronic diarrhea caused by Cyclospora cayetanensis infection

作　　者：徐园园 徐彤彤 魏慕筠 李敏[3] 王长生[2] Xu Yuanyuan;Xu Tongtong;Wei Muyun;Li Min;Wang Changsheng(Department of Infection,Ningbo Hospital,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Ningbo 315336,China;Department of infection,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Laboratory Medicine,Ren Ji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China)

机构地区：[1]上海交通大学医学院附属仁济医院宁波医院感染科,宁波315336 [2]上海交通大学医学院附属仁济医院感染科,上海200127 [3]上海交通大学医学院附属仁济医院检验科,上海200127

出　　处：《中华检验医学杂志》2025年第3期409-411,共3页Chinese Journal of Laboratory Medicine

基　　金：上海市加强公共卫生体系建设三年行动计划(GWVI-11.1-11);国家重点研发计划(2022YFC2603800)。

摘　　要：患者女,66岁,肾移植术后,2024年5月24日因反复间断腹泻16年余,再发30 d就诊上海交通大学附属仁济医院。采集小肠液找寄生虫,小肠液mNGS联合血mNGS均证实为卡晏环孢子虫感染。口服复方磺胺甲噁唑,患者腹泻症状好转。连续复查3次小肠液涂片均未发现卡晏环孢子虫。免疫功能低下患者合并慢性腹泻应排除寄生虫感染因素,无创性小肠液涂片联合mNGS检测为明确慢性腹泻病因提供了新手段。A 66-year-old female kidney transplant recipient presented to Shanghai Jiao Tong University Affiliated Renji Hospital on May 24th,2024 due to recurring intermittent diarrhea for over 16 years.The parasites were found through examination of small intestinal fluid.Small intestinal fluid mNGS combined with blood mNGS confirmed Cyclospora cayetanensis infection.The cause of the diarrhea was clarified.Oral compound sulfamethoxazole was used as treatment,and the patient's diarrhea symptoms improved,and no Cyclospora cayetanensis was found in the small intestinal fluid smear three consecutive times.Parasitic infection factors should be excluded in patients with low immune function and chronic diarrhea.Non-invasive small intestinal fluid smear combined with mNGS detection provides a new method to clarify the cause of chronic diarrhea.

关 键 词：肾移植 慢性腹泻 卡晏环孢子虫 小肠液 

分 类 号：R69[医药卫生—泌尿科学] R692.6[医药卫生—外科学]