傣药拢蒙沙喉散包药法治疗类风湿关节炎风寒湿痹证的临床疗效观察  

Clinical Observation on Treatment of Joint Swelling and Pain of RA of Wind-Cold-Dampness Bi Syndrome with Longmeng Shahou Powder(拢蒙沙喉散)Packaging Method

作　　者：陈敏霞 蒋元韬 张玲[4] 陈艳林[4] 许琳 王丹 李瑞 丁靖 苏义书 章丽萍 CHEN Minxia;JIANG Yuantao;ZHANG Ling;CHEN Yanlin;XU Lin;WANG Dan;LI Rui;DING Jing;SU Yishu;ZHANG Liping(Chuxiong State Hospital of Yi Medicine Research Institute,Chuxiong 675099,Yunnan,China;Chuxiong State Hospital of Traditional Chinese Medicine,Chuxiong 675099,Yunnan,China;First Affiliated Hospital of Hunan Medical College,Huaihua 418000,Hunan,China;Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming 650103,Yunnan,China)

机构地区：[1]楚雄彝族自治州彝族医药研究院,云南楚雄675099 [2]楚雄彝族自治州中医医院,云南楚雄675099 [3]湖南医药学院第一附属医院,湖南怀化418000 [4]云南省中医医院,云南昆明650103

出　　处：《辽宁中医杂志》2025年第4期9-14,共6页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81960863,82160901,82260928);云南省自然科学基金面上项目[2019FF002(-031)]。

摘　　要：目的初步探讨傣药拢蒙沙喉散对类风湿关节炎风寒湿痹证关节局部症状、体征改善作用以及不良反应。方法采用随机双盲安慰剂对照的研究方法,共纳入64例RA风寒湿痹证患者,治疗组予外敷拢蒙沙喉散,对照组予外敷拢蒙沙喉散模拟剂,疗程一共15 d,根据统计软件分析结果来评价拢蒙沙喉散包药法对RA风寒湿痹证关节肿痛的临床疗效及安全性。结果①治疗组的临床疗效总有效率更突出(P<0.05);②中医证候疗效总有效率,治疗组效果更突出(P<0.05);治疗组和对照组的中医证候积分均能降低(P<0.05),治疗组效果更佳(P<0.05);③两组在降低ESR方面效果均不突出(P>0.05);降低CRP方面,治疗组更优(P<0.05);④患者对自身病情的总体评估、疼痛视觉模拟评分、医生对患者病情的总体评估,治疗组效果均比对照组突出(P<0.05);⑤肿胀关节数、压痛关节数、DAS28评分、患者结局临床报告量表评分、握力指数,治疗组效果更佳(P<0.05);⑥双氯芬酸钠肠溶片的服用人数及服药时间对比结果显示差异不影响本次试验(P>0.05);⑦不良反应经对比显示差异不影响本次试验(P>0.05);⑧安全性指标二便常规、心电图均未见明显异常;血常规(WBC、RBC、Hb、PLT)、肝肾功(ALT、AST、BUN、Cr)各项指标在治疗前后差异不影响本次试验(P>0.05)。结论治疗组能更有效改善炎性指标、临床症状、体征,更有效降低DAS28评分、中医证候积分、PRO量表评分。Objective The degree of local joint improvement and adverse events were initially discussed,laying a foundation for future in-depth research and clinical promotion of Longmeng Shahou Powder(拢蒙沙喉散).Methods According to the requirements of the experiment,64 patients were divided into two groups.The treatment group were treated with Longmeng Shahou Powder,and the control group were treated with Longmeng Shahou Powder simulant.The observation period was 15 days.This trialobserved and recorded the safety indicators and efficacy indicatorsto assess the efficacy and safety of Longmeng Shahou Powder by SPSS.Results①The total effective rate of the treatment group was more significantthan that of the control group(P<0.05).②The TCM syndrome effect of the treatment groupwas higher than the that of the control group(P<0.05).Both the treatment group and the control group showed a decrease in traditional Chinese medicine syndrome scores(P<0.05),with the treatment group showing better results(P<0.05).③Both groups showed no significant effect in reducing ESR(P>0.05).In terms of reducing CRP,the treatment group showed better results(P<0.05).④The overall evaluation of the patient′s own condition,pain visual analog scoreand the doctor′s overall evaluation of the patient′s condition of the treatment group had a more significant effect than those of the control group(P<0.05).⑤Number of swollen joints,number of tenderness joints,DAS28 score,patient-reported outcome scale and grip strength index of the treatment group were moresignificant(P<0.05).⑥About taking Diclofenac Sodium Enteric-coated Tabletsof two groups,the difference was not significant in the number or duration(P>0.05).⑦In the course of this study,one patient in the treatment group and one in the control group showed mild adverse reactions,and the difference was not significant between the two groups(P>0.05).⑧Routine stool,urine routine and electrocardiogram were normal.The blood routine test,renalfunctionand hepatic functionbefore and after t

关 键 词：类风湿关节炎 风寒湿痹证 傣药拢蒙沙喉散 外治法 

分 类 号：R255.6[医药卫生—中医内科学]