和胃止痛颗粒的质量控制研究  

Study on Quality Standards of Hewei Zhitong Granule(和胃止痛颗粒)

作　　者：韩康 姜鸿[1] 邸子真[1] 陈妍 于永铎 吕冠华[1] HAN Kang;JIANG Hong;DI Zizhen;CHEN Yan;YU Yongduo;LYU Guanhua(The Second Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang 110034,Liaoning,China;Liaoning University of Traditional Chinese Medicine,Shenyang 110847,Liaoning,China)

机构地区：[1]辽宁中医药大学附属第二医院,辽宁沈阳110034 [2]辽宁中医药大学,辽宁沈阳110847

出　　处：《辽宁中医杂志》2025年第4期146-149,I0004,共5页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省医疗机构制剂创新能力提升项目(辽中医药发【2023】2号18.1)。

摘　　要：目的建立和胃止痛颗粒的质量控制方法。方法采用薄层色谱法对和胃止痛颗粒方中柴胡、延胡索两味药材进行定性鉴别,采用高效液相色谱法对和胃止痛颗粒中芍药苷含量进行测定。结果TLC鉴别分离度和专属性好,阴性供试液无干扰;芍药苷在0.202~1.01μg范围内线性关系良好(r=0.9995),加样回收率均值为100.92%,RSD为1.8%。结论所建方法简便、准确,重复性好,可作为此制剂的质量控制方法。Objective To establish the quality control of Hewei Zhitong Granule(和胃止痛颗粒).Methods Chaihu(Bupleuri Radix)and Yanhusuo(Corydalis Rhizoma)in this preparation were qualitatively identified by thin layer chromatography(TLC).The contents of paeoniflorin were determined by high performance liquid chromatography(HPLC).Results The identification by TLC was distinct and highly specific,and the negative sample did not interfere the identification of TLC.The paeoniflorin showd a good linear relation ship in the range of 0.202~1.01μg(r=0.9995).The average recovery of paeoniflorin was 100.92%,the RSD values(n=9)were 1.8%.Conclusion This method is simple and accurate,and has good repeatability,and it could provide a reference for the quality standard of Hewei Zhitong Granule.

关 键 词：和胃止痛颗粒 质量 薄层色谱 高效液相色谱 柴胡 白芍 延胡索 

分 类 号：R284[医药卫生—中药学]