血液吸附及其抗凝技术的研究进展  

Research progress of hemadsorption and its anticoagulation technology

作　　者：李荣 宋春燕 唐思妍 汤思微 柏明 张鹏 Li Rong;Song Chun-yan;Tang Si-yan;Tang Si-wei;Bai Ming;Zhang Peng(Xi’an Medical University,Xi’an 710021,China;Department of Nephrology,Xijing Hospital,Air Force Medical University,Xi’an 710032,China)

机构地区：[1]西安医学院,西安710021 [2]空军军医大学西京医院肾脏内科,西安710032

出　　处：《临床肾脏病杂志》2025年第4期337-343,共7页Journal Of Clinical Nephrology

基　　金：国家自然科学基金(82070699)。

摘　　要：血液吸附,一般包括血液灌流和血浆吸附,属于血液净化常用技术之一,主要通过吸附柱中的活性炭或树脂清除血液或血浆中的致病物质,达到有效治疗临床疾患的目的。近年来,随着吸附剂生物相容性的提高和新型吸附剂的发展,血液吸附也越来越多地受到血液净化领域的关注。血液经过体外循环,会激活体外凝血系统,抗凝是保障血液吸附顺利进行的关键技术之一。本综述将系统性回顾血液吸附的治疗模式、应用领域及其抗凝模式的最新进展,并对未来的研究方向进行展望。Hemadsorption,generally including hemoperfusion and plasma-adsorption,is one of the common blood purification technologies.It removes pathogenic solutes in blood or plasma through ac⁃tivated carbon or resin in the adsorption column,thus achieving the goal of effectively treating clinical dis⁃eases.In recent years,with the improvement of biocompatibility of adsorbents and the development of new adsorbents,hemadsorption has been increasingly highlighted in the field of blood purification.The blood coagulation system is activated when blood goes through the extracorporeal circulation.Therefore,anticoagulation is one of the key technologies for effective hemadsorption.This review summarized the treatment mode,application field,anticoagulation mode of hemadsorption,and forecasted the future re⁃search direction.

关 键 词：血液吸附 血液灌流 血浆吸附 吸附剂 抗凝 

分 类 号：R457.1[医药卫生—治疗学]